{"id":"W2037404289","doi":"10.1074/jbc.m112.396259","title":"Extracellular Ionic Locks Determine Variation in Constitutive Activity and Ligand Potency between Species Orthologs of the Free Fatty Acid Receptors FFA2 and FFA3","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Wellcome Trust; Canadian Institutes of Health Research; Strategiske Forskningsråd","keywords":"Extracellular; Potency; Receptor; Chemistry; Ligand (biochemistry); Variation (astronomy); Biochemistry; Biology; Cell biology; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003288127,0.0001351857,0.0002202726,0.0003290865,0.0001321986,0.0005098828,0.0002500854,0.0003377275,0.001114811],"category_scores_gemma":[0.0006343473,0.0002018415,0.0002675907,0.0001964919,0.0003225663,0.0002982916,0.0004231131,0.0003936859,0.0003253924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000310345,"about_ca_system_score_gemma":0.0001265577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005747199,"about_ca_topic_score_gemma":0.0008652441,"domain_scores_codex":[0.9996206,0.00006619183,0.00004853577,0.00008658868,0.00008653633,0.00009163553],"domain_scores_gemma":[0.9994875,0.0001545403,0.0001256805,0.00006327521,0.00007549867,0.0000933811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008645494,0.000004461634,0.0006664197,0.000006832183,0.000002856543,0.00002325505,0.00001325785,0.00001871999,0.998746,0.0000513022,0.00000831922,0.0003719739],"study_design_scores_gemma":[0.00002474425,0.0002398594,0.08369603,0.00001224231,0.00004373645,0.0008380027,0.0001326204,0.001571889,0.9109978,0.000196602,0.002224204,0.00002221405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977483,0.0004007092,0.0008960183,0.00002444397,0.000005580611,0.00000648297,0.0001894128,0.00002059017,0.000708409],"genre_scores_gemma":[0.9986325,0.0001276597,0.0004964312,0.00004480613,0.000002396753,0.000009746858,0.0002666028,0.0000138073,0.0004059758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001114811,"threshold_uncertainty_score":0.003729403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01989910896039843,"score_gpt":0.2299487990827554,"score_spread":0.210049690122357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}