{"id":"W2037407093","doi":"10.3390/molecules190914902","title":"1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling","year":2014,"lang":"en","type":"review","venue":"Molecules","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":221,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Juglone; Plumbagin; Oxidative stress; Menadione; Cell biology; Lawsone; Oxidative phosphorylation; Reactive oxygen species; Signal transduction; Chemistry; Pro-oxidant; Redox; Biochemistry; Cell signaling; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002050028,0.0006403664,0.000748172,0.001558973,0.0003295917,0.0007137851,0.0005397844,0.0006319336,0.003471431],"category_scores_gemma":[0.0001545002,0.0002135326,0.0003053734,0.00130375,0.0003622053,0.0009198766,0.0005640188,0.0009741376,0.001772748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000429481,"about_ca_system_score_gemma":0.0006214775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006618295,"about_ca_topic_score_gemma":0.001313455,"domain_scores_codex":[0.9999267,0.000009787246,0.000007919637,0.00001517727,0.00002896004,0.00001147342],"domain_scores_gemma":[0.9999284,0.00001982182,0.000014292,0.000003168024,0.00002387097,0.00001046004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009012035,0.0001500802,0.0002604508,0.02535334,0.0001022116,0.0004500709,0.0001657572,0.0006590809,0.02886686,0.008884362,0.01547041,0.9195473],"study_design_scores_gemma":[0.00001198732,0.0001072061,0.000889695,0.001082908,0.00006042807,0.001348834,0.00008399926,0.0000970691,0.004538065,0.003072118,0.9886911,0.00001646021],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007073748,0.9966575,0.0003565972,0.000213677,0.0001143797,0.00000891405,0.00003208732,0.00001457213,0.001894951],"genre_scores_gemma":[0.0038385,0.9940777,0.0002924282,0.00009450069,0.00008788269,0.000008645064,0.00004815166,0.000001800682,0.001550325],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003471431,"threshold_uncertainty_score":0.01161313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1447821862825263,"score_gpt":0.4342533037244728,"score_spread":0.2894711174419465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}