{"id":"W2037413627","doi":"10.1038/nchembio.563","title":"Molecular insights into the ligand-controlled organization of the SAM-I riboswitch","year":2011,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research","keywords":"Riboswitch; Aptamer; Ligand (biochemistry); Folding (DSP implementation); RNA; Computational biology; Chemistry; Biophysics; Biology; Stereochemistry; Biochemistry; Genetics; Non-coding RNA; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001814857,0.0002559811,0.0001748917,0.000172956,0.0002612703,0.0005115355,0.0005224987,0.000328145,0.002524452],"category_scores_gemma":[0.0002154743,0.0001650239,0.0001904473,0.0001209308,0.0004182465,0.000646997,0.0002495728,0.0008349702,0.0006286885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004002626,"about_ca_system_score_gemma":0.0002213832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002532679,"about_ca_topic_score_gemma":0.0003406225,"domain_scores_codex":[0.9999355,0.000007806409,0.000003145696,0.00001614356,0.00001830324,0.00001903531],"domain_scores_gemma":[0.9999225,0.00003045179,0.00001540613,0.00001019618,0.000006070521,0.00001539318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008059523,0.00002263532,0.0001296838,0.00005857158,0.00000269815,0.0001508865,0.00005023738,0.001210553,0.9795201,0.01396079,0.0001313107,0.004682044],"study_design_scores_gemma":[0.00002572527,0.0001343127,0.0005906366,0.000006267549,0.000006169591,0.0001688159,0.00006815299,0.0138911,0.9739332,0.006882139,0.004277692,0.00001577622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9286446,0.003659024,0.04599747,0.001079755,0.0001473149,0.00004051302,0.0002260698,0.0008005999,0.01940464],"genre_scores_gemma":[0.9914528,0.0007234151,0.005827354,0.0001200296,0.0000310221,0.00001670446,0.00007246272,0.00003829783,0.00171784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002524452,"threshold_uncertainty_score":0.008445203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004707439782138717,"score_gpt":0.2114741131789962,"score_spread":0.2067666733968575,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}