{"id":"W2037420358","doi":"10.1371/journal.pgen.1000592","title":"Evolutionary Processes Acting on Candidate cis-Regulatory Regions in Humans Inferred from Patterns of Polymorphism and Divergence","year":2009,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Human Genome Research Institute; National Institute of General Medical Sciences; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Biology; Genetics; Gene; Natural selection; Candidate gene; Genome; Regulatory sequence; Evolutionary biology; Human genome; Negative selection; Coding region; Selection (genetic algorithm); Computational biology; Regulation of gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006596329,0.000163338,0.0003156791,0.001136663,0.0002505981,0.0003720316,0.000193975,0.0002811216,0.0009756479],"category_scores_gemma":[0.001560925,0.0001781388,0.0002291215,0.0005820809,0.000701875,0.0002641981,0.000269025,0.0002930754,0.0001343876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002157985,"about_ca_system_score_gemma":0.0001477608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008381539,"about_ca_topic_score_gemma":0.001572932,"domain_scores_codex":[0.9996077,0.0001305452,0.00002873504,0.0001546676,0.00004608904,0.00003224488],"domain_scores_gemma":[0.9991135,0.0005353953,0.0001859342,0.00005861912,0.00004662558,0.00006003316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0013897,0.00006630263,0.6146154,0.0002182319,0.0005101887,0.0007688544,0.001904914,0.003998608,0.3313322,0.002650539,0.0001205958,0.04242447],"study_design_scores_gemma":[0.00003658543,0.0001676447,0.9804562,0.00002327664,0.0001095425,0.001258204,0.0003861219,0.006710112,0.006972498,0.003333892,0.0005166719,0.00002913314],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988336,0.0001901123,0.0007361947,0.00001451118,7.445599e-7,0.000002038909,0.00003251631,0.000006504217,0.0001838226],"genre_scores_gemma":[0.9990004,0.00005361632,0.0008161872,0.000009376216,0.000002259552,0.000002473089,0.00006065741,0.000004066774,0.00005097583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001136663,"threshold_uncertainty_score":0.003488481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117582627023437,"score_gpt":0.2212611266477437,"score_spread":0.2100853003775094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}