{"id":"W2037424637","doi":"10.1371/journal.pgen.1004010","title":"A Neurotoxic Glycerophosphocholine Impacts PtdIns-4, 5-Bisphosphate and TORC2 Signaling by Altering Ceramide Biosynthesis in Yeast","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; University of Ottawa","funders":"Canadian Institutes of Health Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft","keywords":"Ceramide; Second messenger system; Biology; Intracellular; Signal transduction; Cell biology; Biochemistry; Phosphatidylinositol; Phospholipase C; Phosphocholine; Phospholipase D; Biosynthesis; Neurotoxicity; Kinase; Saccharomyces cerevisiae; Yeast; Phospholipid; Chemistry; Enzyme; Phosphatidylcholine; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008165898,0.0005265622,0.0002273789,0.0001433234,0.0002263521,0.0004298052,0.0003245785,0.0003009725,0.0008216481],"category_scores_gemma":[0.000102769,0.0001461495,0.0002313509,0.0002284239,0.0002769521,0.0002093794,0.0004331269,0.0003813704,0.0003366568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000479112,"about_ca_system_score_gemma":0.0003033905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002915878,"about_ca_topic_score_gemma":0.002418271,"domain_scores_codex":[0.9998811,0.00001447169,0.00001890796,0.00003102696,0.00003239137,0.00002198845],"domain_scores_gemma":[0.9999224,0.000009548346,0.00002624835,0.00001088658,0.000008596885,0.00002235707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002984637,0.0000253872,0.0001782292,0.00003296785,0.000004652812,0.00007016634,0.0000153256,0.0001726182,0.9980242,0.00008777394,0.00003553138,0.001054556],"study_design_scores_gemma":[0.00002874495,0.0001857758,0.00289866,0.00000678215,0.00001441651,0.0001357718,0.00005856057,0.001261839,0.9933354,0.00007931538,0.001985711,0.000008929774],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994912,0.001004794,0.001596351,0.0001183952,0.00003430279,0.00002409474,0.00104471,0.00009556592,0.001169919],"genre_scores_gemma":[0.9942706,0.0008867593,0.001927362,0.00007467849,0.000005688355,0.00004037525,0.0007044034,0.00004022567,0.002049947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002915878,"threshold_uncertainty_score":0.005797803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006861958281336249,"score_gpt":0.2103723937022152,"score_spread":0.2035104354208789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}