{"id":"W2037424637","doi":"10.1371/journal.pgen.1004010","title":"A Neurotoxic Glycerophosphocholine Impacts PtdIns-4, 5-Bisphosphate and TORC2 Signaling by Altering Ceramide Biosynthesis in Yeast","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; University of Ottawa","funders":"Canadian Institutes of Health Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft","keywords":"Ceramide; Second messenger system; Biology; Intracellular; Signal transduction; Cell biology; Biochemistry; Phosphatidylinositol; Phospholipase C; Phosphocholine; Phospholipase D; Biosynthesis; Neurotoxicity; Kinase; Saccharomyces cerevisiae; Yeast; Phospholipid; Chemistry; Enzyme; Phosphatidylcholine; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002612681,0.0002564066,0.0002903491,0.00009349063,0.00004876034,0.00006127841,0.0002003548,0.0001559805,0.00001301217],"category_scores_gemma":[0.0001884137,0.0002691764,0.00005221025,0.0001634331,0.00005610269,0.000007202772,0.0001340285,0.0001424769,0.000004210331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001731591,"about_ca_system_score_gemma":0.00003115433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004942741,"about_ca_topic_score_gemma":0.00006215411,"domain_scores_codex":[0.9984102,0.0000861851,0.0003708465,0.000500306,0.000161625,0.000470834],"domain_scores_gemma":[0.9993557,0.00002850935,0.00009239432,0.0003234474,0.0000338133,0.0001661753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000764302,0.00007298605,0.01230806,0.00004389168,0.00001504741,0.000004405762,0.00009788671,0.0007152176,0.9847206,0.000006798736,0.00002979346,0.00190889],"study_design_scores_gemma":[0.0009925147,0.0001284534,0.002841447,0.00007608986,0.00001900475,0.000007095366,0.000030258,0.006493746,0.986082,0.00003237039,0.00301033,0.0002867587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944184,0.004823189,0.0002367024,0.0000514784,0.00011612,0.0002279584,0.00001863387,0.00001604171,0.00009150137],"genre_scores_gemma":[0.9971419,0.001419817,0.0006976531,0.0003916021,0.0002122883,0.00002369302,0.00002303739,0.00005907769,0.00003093094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009466609,"threshold_uncertainty_score":0.999976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006861958281336249,"score_gpt":0.2103723937022152,"score_spread":0.2035104354208789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}