{"id":"W2037434478","doi":"10.1016/j.bmcl.2008.10.009","title":"Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: Biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Pharmacophore; Chemistry; Stereochemistry; Celecoxib; Arachidonate 5-lipoxygenase; Enzyme inhibitor; Moiety; Lipoxygenase; Cyclooxygenase; Enzyme; Chemical synthesis; Hydroxamic acid; Biochemistry; Arachidonic acid; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001247815,0.0003990189,0.000468299,0.000224457,0.0002067613,0.0002098195,0.0003747535,0.0002796113,0.002840817],"category_scores_gemma":[0.0001484848,0.000206568,0.0002356192,0.0002439693,0.0001471193,0.0002764822,0.0001761284,0.0004456993,0.0004967023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000221082,"about_ca_system_score_gemma":0.0003676626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004099002,"about_ca_topic_score_gemma":0.0007828373,"domain_scores_codex":[0.9999397,0.000007893017,0.000005778891,0.000009380165,0.0000128971,0.00002444519],"domain_scores_gemma":[0.9999489,0.000005058519,0.00001391701,0.000005069724,0.000006536466,0.00002054188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001779881,0.0005578178,0.0002959779,0.0004060082,0.00004941671,0.0009662326,0.0000819731,0.002529489,0.9549562,0.001836261,0.0007397825,0.03580112],"study_design_scores_gemma":[0.001864284,0.006570356,0.00283233,0.00003718541,0.0001895183,0.001360613,0.00005342632,0.003842028,0.9566566,0.000436445,0.02610452,0.00005267362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9596946,0.00802114,0.01442721,0.0004953246,0.0002906709,0.0008185168,0.001751492,0.0002689302,0.01423209],"genre_scores_gemma":[0.9853691,0.003515261,0.006534963,0.0001369237,0.0000511872,0.0001373909,0.0009970845,0.00001819724,0.003239824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002840817,"threshold_uncertainty_score":0.009503484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02415066431887758,"score_gpt":0.249031469864692,"score_spread":0.2248808055458144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}