{"id":"W2037434478","doi":"10.1016/j.bmcl.2008.10.009","title":"Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: Biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Pharmacophore; Chemistry; Stereochemistry; Celecoxib; Arachidonate 5-lipoxygenase; Enzyme inhibitor; Moiety; Lipoxygenase; Cyclooxygenase; Enzyme; Chemical synthesis; Hydroxamic acid; Biochemistry; Arachidonic acid; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001029309,0.0005977899,0.001229998,0.0001954893,0.0001674623,0.000009360841,0.0001988392,0.0003341459,0.0004447358],"category_scores_gemma":[0.0007297413,0.0004684049,0.0002022773,0.0005049196,0.00128029,0.0001604038,0.00009344806,0.0005088059,0.000008591855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002052723,"about_ca_system_score_gemma":0.0006918572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001613274,"about_ca_topic_score_gemma":0.000003574813,"domain_scores_codex":[0.9961566,0.000228934,0.0007415267,0.0007806746,0.001483233,0.0006090752],"domain_scores_gemma":[0.9974023,0.0004365412,0.0007174039,0.0005852703,0.0002880692,0.0005704315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001380477,0.0004576856,0.03125854,0.001282827,0.0004190787,0.00106374,0.0003372604,0.000004417101,0.9619386,7.006473e-7,0.0006800563,0.001176684],"study_design_scores_gemma":[0.003835289,0.0003447089,0.08476142,0.000664359,0.0007170148,0.001516655,0.0002128577,0.0001030256,0.9073648,0.000001624023,0.00006083993,0.0004173296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966475,0.001118531,0.00002155453,0.0009398814,0.0001626501,0.0008680731,0.00004742625,0.00008595957,0.0001084348],"genre_scores_gemma":[0.9981387,0.0005964866,0.00009835615,0.0003158609,0.0006357769,0.00007695987,0.00005922051,0.00006674306,0.00001187869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05457366,"threshold_uncertainty_score":0.9997768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02415066431887758,"score_gpt":0.249031469864692,"score_spread":0.2248808055458144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}