{"id":"W2037487430","doi":"10.1042/bj20140006","title":"RBR E3 ubiquitin ligases: new structures, new insights, new questions","year":2014,"lang":"en","type":"review","venue":"Biochemical Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":318,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Ubiquitin ligase; Ubiquitin; Ubiquitin-Protein Ligases; Parkin; Cysteine; Ubiquitin-conjugating enzyme; DNA ligase; Thioester; Cell biology; Biochemistry; Deubiquitinating enzyme; Biology; Chemistry; Enzyme; Computational biology; Medicine; Gene; Parkinson's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008934967,0.0006090785,0.001374754,0.0008821688,0.0002684654,0.002107461,0.0007323198,0.001181599,0.002485221],"category_scores_gemma":[0.0005179755,0.0003290711,0.0006214,0.001336242,0.0008430471,0.004551475,0.0007326761,0.001794048,0.002143897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001083483,"about_ca_system_score_gemma":0.0008267742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004653366,"about_ca_topic_score_gemma":0.0006962227,"domain_scores_codex":[0.9997131,0.00005339974,0.00003318503,0.00004649044,0.0001113267,0.00004248897],"domain_scores_gemma":[0.9997985,0.00005887114,0.00003097904,0.00001309392,0.00005928599,0.00003931377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002840401,0.00007039092,0.0007944212,0.01290839,0.0002073402,0.001197232,0.0006110938,0.001614915,0.02763298,0.03487634,0.07051228,0.8492905],"study_design_scores_gemma":[0.00001126274,0.00005927611,0.0004415541,0.000529723,0.00004466291,0.001489337,0.0002250265,0.0002064465,0.001574748,0.007084875,0.9883118,0.00002119859],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007721281,0.9949552,0.0006857573,0.001899325,0.0004172724,0.000002738817,0.00004057187,0.00003023023,0.001196802],"genre_scores_gemma":[0.004328977,0.9906317,0.001062612,0.001393836,0.0007515821,0.000007973436,0.0001548863,0.000008560623,0.001659867],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002485221,"threshold_uncertainty_score":0.008313894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03289483512452572,"score_gpt":0.3134063800532698,"score_spread":0.2805115449287441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}