{"id":"W2037493363","doi":"10.1002/chir.20718","title":"CD‐sensitive Zn‐porphyrin tweezer host‐guest complexes, part 2: <i>Cis‐</i> and <i>trans‐</i>3‐hydroxy‐4‐aryl/alkyl‐β‐lactams. A case study","year":2009,"lang":"en","type":"article","venue":"Chirality","topic":"Synthesis of β-Lactam Compounds","field":"Chemistry","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick","funders":"","keywords":"Chemistry; Stereocenter; Chirality (physics); Porphyrin; OPLS; Alkyl; Atropisomer; Aryl; Reactivity (psychology); Supramolecular chemistry; Stereochemistry; Hydrogen bond; Absolute configuration; Molecular recognition; Molecule; Enantioselective synthesis; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000817576,0.0008538542,0.001122016,0.0001109683,0.0005355707,0.0002547093,0.0004896056,0.0003063272,0.0003983877],"category_scores_gemma":[0.0002069665,0.0008567685,0.0002960027,0.0003008656,0.0003890945,0.0004361792,0.0002016919,0.0007586738,0.0000639287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001806393,"about_ca_system_score_gemma":0.00009412183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001432708,"about_ca_topic_score_gemma":0.0006603412,"domain_scores_codex":[0.9957376,0.0002133706,0.0009775982,0.001385256,0.0007074153,0.0009788234],"domain_scores_gemma":[0.9967598,0.0005889706,0.0003424962,0.001573146,0.0001728214,0.0005627651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001558773,0.01649383,0.2540883,0.0007774628,0.001647569,0.03481149,0.01863867,0.00001552033,0.6264147,0.000526627,0.02969494,0.01533211],"study_design_scores_gemma":[0.01512074,0.002397001,0.2985746,0.001300612,0.0021982,0.01812741,0.01742635,0.0004369612,0.5274508,0.001501244,0.1065338,0.008932387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803733,0.0003470732,0.00002700326,0.0009015127,0.0003358717,0.0005194298,0.0002187604,0.0005115024,0.01676551],"genre_scores_gemma":[0.9970897,0.00003925912,0.0001846483,0.0009146963,0.000892675,0.00003712322,0.0000536501,0.00008377523,0.0007044242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09896394,"threshold_uncertainty_score":0.9993883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02583963139738191,"score_gpt":0.2664732605599022,"score_spread":0.2406336291625203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}