{"id":"W2037501805","doi":"10.1038/sj.gt.3301308","title":"Stabilized plasmid-lipid particles for systemic gene therapy","year":2000,"lang":"en","type":"article","venue":"Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Inimex Pharmaceuticals (Canada)","funders":"","keywords":"Plasmid; Genetic enhancement; Molecular biology; Gene delivery; Transfection; Liposome; Cationic liposome; DNA; Gene; Biology; Vector (molecular biology); Chemistry; Biochemistry; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001997135,0.0002378533,0.0002299451,0.0000303679,0.0001164142,0.00003947055,0.000299499,0.0001567276,0.0003805375],"category_scores_gemma":[0.000006996312,0.0001996685,0.00019936,0.00006937944,0.00006218886,0.000006323216,0.00001467159,0.00005103484,0.00007604222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001431283,"about_ca_system_score_gemma":0.00007584693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001875906,"about_ca_topic_score_gemma":0.000007391809,"domain_scores_codex":[0.9986661,0.00007936219,0.0002890565,0.000451179,0.0001236057,0.0003906969],"domain_scores_gemma":[0.9992068,0.00001882016,0.00006735446,0.0005165678,0.0001000908,0.00009031882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001663301,0.00009333454,0.0002958431,0.000005262302,0.0001283496,0.000001448092,0.0001291368,0.0001735988,0.9284788,0.000005422879,0.003098204,0.06592733],"study_design_scores_gemma":[0.002522106,0.0009934747,0.0002084836,0.000007650954,0.000006774707,0.00003169412,0.00004623312,0.00009951085,0.9136709,0.0001021394,0.08205032,0.0002607098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990622,0.007612761,0.0005934145,0.0002334715,0.0001580274,0.0005786288,0.0000458398,0.00003715859,0.0001186716],"genre_scores_gemma":[0.9759704,0.01940246,0.0007713525,0.001411953,0.0007351197,0.0002410203,0.0001560133,0.00004887882,0.00126279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07895212,"threshold_uncertainty_score":0.8142247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02325505145735862,"score_gpt":0.26142748739043,"score_spread":0.2381724359330714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}