{"id":"W2037501805","doi":"10.1038/sj.gt.3301308","title":"Stabilized plasmid-lipid particles for systemic gene therapy","year":2000,"lang":"en","type":"article","venue":"Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":148,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Inimex Pharmaceuticals (Canada)","funders":"","keywords":"Plasmid; Genetic enhancement; Molecular biology; Gene delivery; Transfection; Liposome; Cationic liposome; DNA; Gene; Biology; Vector (molecular biology); Chemistry; Biochemistry; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003050609,0.000434128,0.0004850314,0.0004642865,0.0002802636,0.0003889689,0.0002702052,0.000503545,0.001365166],"category_scores_gemma":[0.0001882309,0.0002523907,0.0002464797,0.0003395961,0.0004132686,0.0003764776,0.0003568898,0.000881395,0.0007546782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004395772,"about_ca_system_score_gemma":0.0004349221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002965485,"about_ca_topic_score_gemma":0.0005420785,"domain_scores_codex":[0.9998753,0.00002100061,0.000007582585,0.00002169262,0.00005207869,0.00002230963],"domain_scores_gemma":[0.9999235,0.00002558028,0.00001668067,0.00001075434,0.00001050321,0.00001299688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006510937,0.00001700926,0.00003225949,0.00008638704,0.000005256744,0.00004744041,0.00002373277,0.0001276449,0.9930316,0.001451322,0.0001515242,0.004960661],"study_design_scores_gemma":[0.0000194347,0.00009054705,0.0001281449,0.000005377723,0.00001363807,0.0001162111,0.000004853621,0.0004571965,0.9945912,0.0002687245,0.004299929,0.000004771961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5403313,0.01879354,0.4248977,0.0009151616,0.000443073,0.0006203885,0.0007523199,0.00191513,0.01133129],"genre_scores_gemma":[0.8949361,0.008168839,0.07864757,0.0001775642,0.00007080106,0.0004294726,0.0008839636,0.0003709318,0.01631462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001365166,"threshold_uncertainty_score":0.004566908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02325505145735862,"score_gpt":0.26142748739043,"score_spread":0.2381724359330714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}