{"id":"W2037504547","doi":"10.1371/journal.ppat.1004240","title":"LANA Binds to Multiple Active Viral and Cellular Promoters and Associates with the H3K4Methyltransferase hSET1 Complex","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; Broad Institute; University of Florida","keywords":"H3K4me3; Promoter; Biology; Chromatin immunoprecipitation; Lytic cycle; Kaposi's sarcoma-associated herpesvirus; Sequence motif; Epigenetics; Chromatin; Gene; Molecular biology; Binding site; Genetics; Gene expression; Virus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001849139,0.0004887995,0.000457639,0.0006443709,0.0005451758,0.0006143551,0.0003738131,0.0002373692,0.005816142],"category_scores_gemma":[0.0002342655,0.0003755447,0.0008334428,0.0003865554,0.0002762287,0.000485037,0.0008518934,0.0005412104,0.002360542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008279111,"about_ca_system_score_gemma":0.0002613886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002172647,"about_ca_topic_score_gemma":0.003773303,"domain_scores_codex":[0.9997209,0.00002020646,0.00001079975,0.0001149019,0.00006922235,0.00006393881],"domain_scores_gemma":[0.9998268,0.00002213364,0.00005178526,0.00001811042,0.00002799182,0.00005317012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003341459,0.00003600011,0.006285351,0.0002283639,0.00006075902,0.0001090267,0.00006173419,0.0002178385,0.9860246,0.0001542495,0.0003735106,0.006114441],"study_design_scores_gemma":[0.00004095548,0.0002609733,0.1541652,0.00004243476,0.00009716212,0.0005325952,0.0001896061,0.005248441,0.8242333,0.0003996087,0.01474655,0.00004306969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719381,0.007778774,0.01113175,0.0001868112,0.00004348301,0.00004346286,0.003248973,0.000911197,0.004717532],"genre_scores_gemma":[0.9763842,0.001461104,0.005945332,0.0001584389,0.00002805533,0.00005745687,0.00811072,0.0001611149,0.007693512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005816142,"threshold_uncertainty_score":0.01945692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428074883021103,"score_gpt":0.2235244250176357,"score_spread":0.2092436761874246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}