{"id":"W2037504547","doi":"10.1371/journal.ppat.1004240","title":"LANA Binds to Multiple Active Viral and Cellular Promoters and Associates with the H3K4Methyltransferase hSET1 Complex","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; Broad Institute; University of Florida","keywords":"H3K4me3; Promoter; Biology; Chromatin immunoprecipitation; Lytic cycle; Kaposi's sarcoma-associated herpesvirus; Sequence motif; Epigenetics; Chromatin; Gene; Molecular biology; Binding site; Genetics; Gene expression; Virus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001708346,0.0001840123,0.0003057485,0.00005711049,0.0001878367,0.0000335011,0.00005830118,0.00008041529,0.00002063315],"category_scores_gemma":[0.0001153751,0.0001179693,0.00004515457,0.0001453644,0.0001041544,0.0000465598,0.00002589128,0.000171842,0.000006654146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005398349,"about_ca_system_score_gemma":0.00003274331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001197473,"about_ca_topic_score_gemma":0.0002267397,"domain_scores_codex":[0.998946,0.000092786,0.0001181583,0.0003015274,0.0002350827,0.0003064619],"domain_scores_gemma":[0.9993992,0.0001223895,0.00004756,0.0001775722,0.00006509135,0.000188153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007770034,0.000321442,0.1382625,0.0001123977,0.0005248477,0.00003166632,0.008069956,0.00001219652,0.837953,0.00006837721,0.001324784,0.01254185],"study_design_scores_gemma":[0.024825,0.008855927,0.7488333,0.0004080261,0.002499623,0.00003246722,0.01122648,0.005466022,0.1822164,0.0004169743,0.01352282,0.001696988],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937378,0.0001030558,0.0002322589,0.004539707,0.00001812184,0.0005916874,0.0001339152,0.00005207132,0.000591421],"genre_scores_gemma":[0.9976783,0.0000233615,0.0003690209,0.001636464,0.00005591411,0.0000324444,0.00004988144,0.0000311038,0.0001235547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6557366,"threshold_uncertainty_score":0.4810649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428074883021103,"score_gpt":0.2235244250176357,"score_spread":0.2092436761874246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}