{"id":"W2037505831","doi":"10.1371/journal.pone.0106487","title":"High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; McMaster University","funders":"Kuwait University; Heart and Stroke Foundation of Canada","keywords":"S1PR1; Sphingosine-1-phosphate receptor; Sphingosine-1-phosphate; Sphingosine; Cell biology; Receptor; Biology; Sphingosine kinase; Pertussis toxin; Scavenger receptor; Cell migration; Signal transduction; G protein-coupled receptor; Protein kinase B; Chemistry; Biochemistry; G protein; Lipoprotein; Cell; Cancer research; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002633365,0.0001748998,0.0002493546,0.00002732257,0.0001220437,0.00003760297,0.0001023289,0.000154265,0.00009814519],"category_scores_gemma":[0.0001460907,0.000136751,0.00003045817,0.00009071323,0.00009810779,0.000006499685,0.00005826302,0.0001119836,0.000008329373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005241692,"about_ca_system_score_gemma":0.00001373283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000231547,"about_ca_topic_score_gemma":0.00001742473,"domain_scores_codex":[0.9990043,0.00009068421,0.000209293,0.0003333568,0.0001850253,0.0001773075],"domain_scores_gemma":[0.9993742,0.00003357529,0.0001191513,0.0002795768,0.0001188926,0.00007466695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000400174,0.0001700255,0.0006476551,0.00004293563,0.0001189884,1.950163e-7,0.00008549188,0.000002752758,0.9945999,0.00003164219,0.001451493,0.002448716],"study_design_scores_gemma":[0.00067465,0.0003115334,0.001323878,0.00006847816,0.00007667129,8.235615e-7,0.00001321188,0.0003221302,0.9938462,0.00002788535,0.00317556,0.0001589908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973258,0.001479025,0.00002119176,0.0007893501,0.00005870622,0.0002372076,0.00004970752,0.00001412333,0.00002492643],"genre_scores_gemma":[0.9963414,0.001418617,0.0009810777,0.0005090349,0.0002060653,0.000009074505,0.0001378941,0.00002577874,0.0003710221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002289725,"threshold_uncertainty_score":0.5576543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158848704725794,"score_gpt":0.199844235675594,"score_spread":0.1882557486283361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}