{"id":"W2037505831","doi":"10.1371/journal.pone.0106487","title":"High Density Lipoprotein Stimulated Migration of Macrophages Depends on the Scavenger Receptor Class B, Type I, PDZK1 and Akt1 and Is Blocked by Sphingosine 1 Phosphate Receptor Antagonists","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; McMaster University","funders":"Kuwait University; Heart and Stroke Foundation of Canada","keywords":"S1PR1; Sphingosine-1-phosphate receptor; Sphingosine-1-phosphate; Sphingosine; Cell biology; Receptor; Biology; Sphingosine kinase; Pertussis toxin; Scavenger receptor; Cell migration; Signal transduction; G protein-coupled receptor; Protein kinase B; Chemistry; Biochemistry; G protein; Lipoprotein; Cell; Cancer research; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522193,0.0004318603,0.0002121599,0.0002181179,0.0002433331,0.0002206084,0.0002048184,0.0002082751,0.002546607],"category_scores_gemma":[0.0001162504,0.0001898285,0.0002547661,0.0001489937,0.0002596207,0.0001599822,0.0002334679,0.0006590076,0.0008045576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002968124,"about_ca_system_score_gemma":0.0005217007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007087411,"about_ca_topic_score_gemma":0.001138679,"domain_scores_codex":[0.9998524,0.0000235259,0.00001197773,0.00002025809,0.00003262145,0.00005917271],"domain_scores_gemma":[0.9999348,0.00000675309,0.00001721043,0.000007103264,0.000009160059,0.00002499615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00074767,0.00008649825,0.0001318396,0.00005676606,0.000006574045,0.00005167032,0.00001171151,0.00003495942,0.996595,0.0001814118,0.0000973921,0.001998653],"study_design_scores_gemma":[0.0002101734,0.0008279515,0.0124871,0.00001718712,0.00002622882,0.0002409461,0.00004622615,0.001213314,0.9798816,0.000136754,0.00490415,0.000008318362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886956,0.003307703,0.002560207,0.0004057555,0.00008153552,0.00004949088,0.0003622894,0.0001086052,0.004428744],"genre_scores_gemma":[0.9843609,0.003049417,0.002583351,0.0001090368,0.00002435834,0.0001255476,0.0008131361,0.00001514844,0.008919101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002546607,"threshold_uncertainty_score":0.008519232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01158848704725794,"score_gpt":0.199844235675594,"score_spread":0.1882557486283361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}