{"id":"W2037534474","doi":"10.1016/j.bmc.2003.06.005","title":"Engineering charge selectivity in model ion channels","year":2003,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Alamethicin; Chemistry; Selectivity; Helix (gastropod); Ion; Ion channel; Peptide; Lysine; Amino acid; Stereochemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002865897,0.0002340749,0.0002689909,0.0001287263,0.0002449572,0.0005423657,0.0004031038,0.0003785975,0.0008015808],"category_scores_gemma":[0.0005005868,0.000117764,0.0001772376,0.0001351923,0.0003981649,0.0004634539,0.0002637071,0.000743003,0.0002207839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000598472,"about_ca_system_score_gemma":0.0003173079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004189832,"about_ca_topic_score_gemma":0.0004862533,"domain_scores_codex":[0.9998952,0.00002476016,0.000008958544,0.0000170663,0.00003223232,0.00002186484],"domain_scores_gemma":[0.9998354,0.0000813372,0.00002571303,0.00001603122,0.00001647207,0.0000250451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004384622,0.0001304874,0.0004052775,0.0001081282,0.00001408055,0.0002627193,0.00005436425,0.007870511,0.9522608,0.02961957,0.000367792,0.008467869],"study_design_scores_gemma":[0.0001813885,0.0003249403,0.0002916562,0.00001064429,0.00002135921,0.0003809345,0.00006062147,0.04956069,0.936295,0.007386986,0.005455558,0.00003021672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690711,0.0003075463,0.02657849,0.0004559986,0.00008964458,0.0000582539,0.00008525246,0.0002156561,0.003138094],"genre_scores_gemma":[0.9929999,0.0002845085,0.005577828,0.0000993155,0.000008640978,0.00001817013,0.00004452045,0.00003558306,0.0009314697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008015808,"threshold_uncertainty_score":0.004342258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071577584658905,"score_gpt":0.2174481599685248,"score_spread":0.2067323841219357,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}