{"id":"W2037647662","doi":"10.1080/15459620590909673","title":"Physiologically Based Modeling of n-Hexane Kinetics in Humans Following Inhalation Exposure at Rest and Under Physical Exertion: Impact on Free 2,5-Hexanedione in Urine and on n-Hexane in Alveolar Air","year":2005,"lang":"en","type":"article","venue":"Journal of Occupational and Environmental Hygiene","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut de recherche Robert-Sauvé en santé et en sécurité du travail; Sante Montreal; Université de Montréal","funders":"Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail","keywords":"Inhalation; Inhalation exposure; Chemistry; Physiologically based pharmacokinetic modelling; Pharmacokinetics; Urine; Confidence interval; Toxicokinetics; Animal science; Toxicology; Toxicity; Pharmacology; Anesthesia; Internal medicine; Medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001589225,0.0001266218,0.0002002883,0.0001096433,0.00002697898,0.000005147256,0.00004656399,0.00007558169,0.000007441614],"category_scores_gemma":[0.00001589066,0.0001030607,0.00006002577,0.00004556999,0.00004464911,0.00001576474,0.00006000311,0.0001102392,1.406127e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009636456,"about_ca_system_score_gemma":0.00001578209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001353576,"about_ca_topic_score_gemma":0.00006996297,"domain_scores_codex":[0.9991555,0.00004478686,0.0003091534,0.0001767745,0.0001989352,0.0001148896],"domain_scores_gemma":[0.9997076,0.00002768818,0.0001082235,0.00008816297,0.000007960013,0.0000603664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009724049,0.0005532146,0.09427065,0.00000916524,0.00001357372,0.000008604316,0.00005719997,0.2349258,0.6685712,0.000008204785,0.000003884368,0.0006060392],"study_design_scores_gemma":[0.002319797,0.001704293,0.9680356,0.0000633212,0.000009858677,0.00001249168,0.00006354769,0.0128218,0.014759,0.00009250127,0.00001001244,0.0001077955],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992513,0.0003045837,0.0001253167,0.0001794838,0.00001303964,0.00008903438,0.00002293154,6.654189e-7,0.00001365794],"genre_scores_gemma":[0.9991828,0.0001789264,0.0003654803,0.0001180293,0.00008065448,0.000002660459,0.00005806968,0.000006910526,0.00000649486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8737649,"threshold_uncertainty_score":0.4202692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01407835441638082,"score_gpt":0.2690746534255027,"score_spread":0.2549962990091219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}