{"id":"W2037653168","doi":"10.1021/ol005860z","title":"Novel Natural Products from Soil DNA Libraries in a Streptomycete Host","year":2000,"lang":"en","type":"article","venue":"Organic Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":262,"is_retracted":false,"has_abstract":true,"ca_institutions":"TerraBioGen (Canada); University of British Columbia","funders":"","keywords":"Recombinant DNA; Streptomyces; Chemistry; Cloning (programming); DNA; Host (biology); Stereochemistry; Soil bacteria; Molecular cloning; Bacteria; Biochemistry; Gene; Genetics; Biology; Peptide sequence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002052923,0.0004571747,0.0003908963,0.0005311126,0.0001738822,0.0005134852,0.0002872054,0.0002114625,0.002002531],"category_scores_gemma":[0.0003159007,0.0002465483,0.0002007774,0.0006204773,0.0001600674,0.000167603,0.000272912,0.0004143053,0.000872997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002585124,"about_ca_system_score_gemma":0.0003951419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002707767,"about_ca_topic_score_gemma":0.0008069347,"domain_scores_codex":[0.9997705,0.00004887337,0.00001665037,0.00004669938,0.00007855658,0.00003877737],"domain_scores_gemma":[0.9997866,0.00005182294,0.00004141208,0.00002122246,0.00002675755,0.00007224468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002019592,0.00004510085,0.0002539788,0.0000651884,0.000008560429,0.0001090976,0.0000196026,0.0002569799,0.9925497,0.0001451563,0.00005348457,0.006291322],"study_design_scores_gemma":[0.00007434555,0.001059277,0.001828038,0.00001472757,0.00004341528,0.0005804594,0.00003698457,0.001119532,0.9889905,0.0001412885,0.006098053,0.00001329606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9636707,0.001659215,0.02543854,0.0001443587,0.00005052815,0.0002914846,0.002787443,0.000837065,0.00512061],"genre_scores_gemma":[0.9378928,0.00189486,0.04044532,0.0001524121,0.00003186175,0.0002337345,0.009424986,0.0001541928,0.009769818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002002531,"threshold_uncertainty_score":0.006699145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007411977921555695,"score_gpt":0.1898449005654413,"score_spread":0.1824329226438856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}