{"id":"W2037653168","doi":"10.1021/ol005860z","title":"Novel Natural Products from Soil DNA Libraries in a Streptomycete Host","year":2000,"lang":"en","type":"article","venue":"Organic Letters","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":262,"is_retracted":false,"has_abstract":true,"ca_institutions":"TerraBioGen (Canada); University of British Columbia","funders":"","keywords":"Recombinant DNA; Streptomyces; Chemistry; Cloning (programming); DNA; Host (biology); Stereochemistry; Soil bacteria; Molecular cloning; Bacteria; Biochemistry; Gene; Genetics; Biology; Peptide sequence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00007591685,0.0002112257,0.0003037497,0.00008322384,0.00005302918,0.00005752801,0.0001586622,0.00008678641,0.002272085],"category_scores_gemma":[0.0001441818,0.0001603228,0.00005525036,0.000426012,0.00009682341,0.0002339082,0.00004092822,0.0003601541,0.0002611499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000756546,"about_ca_system_score_gemma":0.00008612934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003090716,"about_ca_topic_score_gemma":0.00005829901,"domain_scores_codex":[0.9986997,0.00002463512,0.000249138,0.0005024978,0.0001845237,0.0003395235],"domain_scores_gemma":[0.9994248,0.00003911543,0.00004834117,0.0003968398,0.00002614417,0.00006482821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001518839,0.000083684,0.000588145,0.00002867715,0.00004267813,0.00005430468,0.0003438067,1.83173e-7,0.9830119,0.000004662847,0.01190798,0.003782105],"study_design_scores_gemma":[0.001082178,0.00003190289,0.02613585,0.0001128997,0.00004569254,0.00004497219,0.00003152135,0.000007944299,0.9630493,0.000005356883,0.009223662,0.0002287283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9180928,0.0004411312,9.002018e-7,0.08071421,0.0002534331,0.0002529177,0.00002401281,0.0000884353,0.0001321525],"genre_scores_gemma":[0.9860051,0.00004558138,0.0009472868,0.01104299,0.0007570619,8.202564e-7,0.00006493448,0.00003643761,0.001099764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06967122,"threshold_uncertainty_score":0.99864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007411977921555695,"score_gpt":0.1898449005654413,"score_spread":0.1824329226438856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}