{"id":"W2037678181","doi":"10.1385/cbb:43:2:231","title":"Synergistic Inhibition of the Maximum Conductance of Kv1.5 Channels by Extracellular K<SUP>+</SUP> Reduction and Acidification","year":2005,"lang":"en","type":"review","venue":"Cell Biochemistry and Biophysics","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; St. Boniface Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Extracellular; Biophysics; Chemistry; Potassium channel; Membrane potential; Ion channel; SK channel; Conductance; Calcium-activated potassium channel; Potassium; Shaker; Voltage-gated potassium channel; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001655736,0.0004076473,0.0005645516,0.00003977917,0.0001240463,0.00002601374,0.0001553025,0.0006557957,0.0000110514],"category_scores_gemma":[0.00003431055,0.0003352787,0.0002441303,0.0002419857,0.0004052181,0.00001307695,0.000102503,0.0001835532,0.000001956802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003146709,"about_ca_system_score_gemma":0.0001024898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001739393,"about_ca_topic_score_gemma":1.013101e-7,"domain_scores_codex":[0.9982927,0.00008383783,0.000597531,0.000612753,0.0002089334,0.0002042852],"domain_scores_gemma":[0.9984644,0.00001636074,0.000758428,0.0004983458,0.0001795929,0.00008284255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002414423,0.0001115729,3.784238e-7,0.004059646,0.00004650063,2.495646e-7,0.00002705506,0.00001838267,0.9371068,0.00004169983,0.0008603507,0.05770322],"study_design_scores_gemma":[0.0002518902,0.00006693524,4.441334e-7,0.0007706457,0.0002436489,0.00001764577,0.0000435916,0.00009361558,0.8078761,0.00005719149,0.1902612,0.0003170254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08437262,0.9135532,0.0005776057,0.00004298308,0.0003426585,0.000517057,0.0002938405,0.00001397187,0.0002860865],"genre_scores_gemma":[0.2716477,0.7239875,0.00007044797,0.0000077133,0.0007420658,0.00003513716,0.001775279,0.00003599402,0.001698202],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1895657,"threshold_uncertainty_score":0.9999099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01661739490277348,"score_gpt":0.2375619076887806,"score_spread":0.2209445127860072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}