{"id":"W2037680215","doi":"10.2174/1389450111314030005","title":"Inhibition of Matrix Metalloproteinases (MMPs) as a Potential Strategy to Ameliorate Hypertension-Induced Cardiovascular Alterations","year":2013,"lang":"en","type":"review","venue":"Current Drug Targets","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Matrix metalloproteinase; Proteases; Extracellular matrix; Vascular smooth muscle; Endothelial dysfunction; Medicine; Angiotensin II; Oxidative stress; Downregulation and upregulation; Pharmacology; Internal medicine; Endocrinology; Cell biology; Bioinformatics; Receptor; Biology; Enzyme; Biochemistry; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003008783,0.0006307472,0.001438289,0.0002412674,0.0001352229,0.00007257222,0.0002933626,0.0003401994,0.00006991119],"category_scores_gemma":[0.0001113219,0.0005386602,0.00145219,0.0002713407,0.00003828124,0.00001927755,0.0002820988,0.0002954066,0.0002881536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003790445,"about_ca_system_score_gemma":0.0004581377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007490686,"about_ca_topic_score_gemma":0.000003086619,"domain_scores_codex":[0.9970886,0.0003442572,0.0008123765,0.0008803495,0.0004405855,0.0004338186],"domain_scores_gemma":[0.9980509,0.000008480697,0.0003710323,0.0009134102,0.0003917592,0.0002643908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002313876,0.0003574157,5.681992e-8,0.005353763,0.001130514,0.00004520404,0.0000232806,0.00008813809,0.2241569,0.0001690791,0.004931767,0.7637208],"study_design_scores_gemma":[0.000353355,0.0003932868,1.179709e-7,0.002935832,0.001258218,0.00006685771,0.00002187473,0.00001321318,0.2551966,0.0001800566,0.7388043,0.000776292],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004956097,0.990185,0.0009355795,0.00000958512,0.0009124032,0.002726014,0.0001798176,0.00002931119,0.00006623093],"genre_scores_gemma":[0.01967033,0.9756337,0.0004311899,0.00002395514,0.0009761383,0.000983916,0.002023592,0.00009823163,0.0001589018],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7629445,"threshold_uncertainty_score":0.9997065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04007621715748944,"score_gpt":0.3123919472443425,"score_spread":0.2723157300868531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}