{"id":"W2037695150","doi":"10.1371/journal.pone.0082076","title":"Initial Cell Seeding Density Influences Pancreatic Endocrine Development During in vitro Differentiation of Human Embryonic Stem Cells","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Michael Smith Health Research BC; Stem Cell Network","keywords":"PDX1; Biology; Progenitor cell; PAX4; Stem cell; Embryonic stem cell; Cellular differentiation; Enteroendocrine cell; Cell biology; Internal medicine; Endocrinology; Endocrine system; Insulin; Hormone; Medicine; Islet; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005607391,0.0005752183,0.0005767253,0.0003016723,0.0002963309,0.0008335011,0.0004372719,0.0003887613,0.00122911],"category_scores_gemma":[0.0009017379,0.000365941,0.0002737449,0.0003806414,0.0002518623,0.0003744696,0.000486092,0.0005994719,0.0003882835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005125446,"about_ca_system_score_gemma":0.0003201914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00296531,"about_ca_topic_score_gemma":0.00497613,"domain_scores_codex":[0.9993165,0.0001351145,0.0001170034,0.0001479258,0.0001800515,0.0001035113],"domain_scores_gemma":[0.9992501,0.0003833391,0.00009395547,0.0000416261,0.0001497142,0.00008121055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000278401,0.0001296564,0.002260742,0.0001869329,0.00001685184,0.000151144,0.0002416816,0.0003244675,0.9931249,0.000103259,0.0001498623,0.003032122],"study_design_scores_gemma":[0.0000160588,0.0005622915,0.01745096,0.00003940364,0.00007321577,0.0001319014,0.0001505899,0.001818891,0.9776289,0.00003251118,0.002079117,0.00001622184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874729,0.003943617,0.003553366,0.00009365864,0.00009987401,0.0001683561,0.0004359947,0.00008260327,0.004149582],"genre_scores_gemma":[0.9841051,0.003670597,0.009022902,0.0001312476,0.00004286095,0.0001939386,0.0008872694,0.00006718556,0.001879037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00296531,"threshold_uncertainty_score":0.005896091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03473679344785988,"score_gpt":0.231464714553877,"score_spread":0.1967279211060171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}