{"id":"W2037699975","doi":"10.1371/journal.pone.0073206","title":"Loss of the Osteogenic Differentiation Potential during Senescence Is Limited to Bone Progenitor Cells and Is Dependent on p53","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Université de Montréal","keywords":"Senescence; Adipogenesis; Progenitor cell; Cell biology; Osteoblast; Stromal cell; Biology; Downregulation and upregulation; Mesenchymal stem cell; DNA damage; Bone marrow; Population; Cellular differentiation; Stem cell; Cancer research; Chemistry; Immunology; In vitro; Medicine; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002568541,0.0002156198,0.0002770633,0.000297451,0.0002027894,0.0003991359,0.000142934,0.0001904631,0.001143964],"category_scores_gemma":[0.0003209377,0.0001476073,0.0002679616,0.000177407,0.0003088291,0.0002621791,0.0002641384,0.0003958998,0.0003753597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001243525,"about_ca_system_score_gemma":0.0002189528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002312475,"about_ca_topic_score_gemma":0.0003856176,"domain_scores_codex":[0.9998344,0.00002566961,0.00002607109,0.00003154711,0.00005384265,0.00002836691],"domain_scores_gemma":[0.9996706,0.00008181699,0.00009409852,0.00007076014,0.0000425305,0.00004012125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006754726,0.00001344179,0.0006764571,0.00003936136,0.000004197752,0.0001015608,0.00002339078,0.00002744142,0.9966004,0.0001458578,0.00001587776,0.002284444],"study_design_scores_gemma":[0.00000830092,0.0002842133,0.01674664,0.00001462564,0.00001570703,0.0008524383,0.00005310647,0.0004000876,0.9779763,0.0002018436,0.003442985,0.00000382283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821093,0.005783551,0.008963922,0.0001427879,0.00003141681,0.00003455183,0.0002535787,0.00008353928,0.002597352],"genre_scores_gemma":[0.9945689,0.002268707,0.00131506,0.00003678294,0.00001105128,0.00002787485,0.000201379,0.00001507154,0.00155521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001143964,"threshold_uncertainty_score":0.003826916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0179389682189146,"score_gpt":0.2051503190939607,"score_spread":0.1872113508750461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}