{"id":"W2037708347","doi":"10.1038/ni947","title":"Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell–dependent B cell responses","year":2003,"lang":"en","type":"article","venue":"Nature Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":203,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McMaster University Medical Centre; Canadian Institute for Advanced Research; McMaster University; University of Toronto; Ontario Institute for Cancer Research","funders":"Amgen","keywords":"T cell; Cell biology; Cell; Adoptive cell transfer; Phenotype; Ligand (biochemistry); In vivo; Chemistry; Immunology; Biology; Receptor; Immune system; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002668933,0.0005123499,0.0002903042,0.0002788162,0.0003234269,0.0008676804,0.0003475714,0.0004487089,0.001374302],"category_scores_gemma":[0.0003945858,0.0002407023,0.0001843037,0.0001864418,0.0002229895,0.0004749559,0.0005433923,0.001255895,0.001319317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006576903,"about_ca_system_score_gemma":0.0004099956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000288077,"about_ca_topic_score_gemma":0.0005728828,"domain_scores_codex":[0.9996201,0.0000799163,0.00003805167,0.00005249322,0.0001020275,0.000107474],"domain_scores_gemma":[0.9995112,0.00005906537,0.0001470776,0.00006849828,0.00007564417,0.0001385309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000115915,0.00003027129,0.0003124327,0.00002187001,0.000003033193,0.00004696085,0.000007892611,0.00006083413,0.9965574,0.0003527463,0.0001103727,0.002380272],"study_design_scores_gemma":[0.000041406,0.0001762522,0.005416211,0.00001146884,0.0000224401,0.0004130939,0.0000295908,0.001954226,0.9861336,0.0001856754,0.005607452,0.000008611054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896564,0.002542622,0.005141048,0.000245003,0.00009793445,0.00002695433,0.0001848905,0.0001908387,0.001914324],"genre_scores_gemma":[0.992239,0.0006968172,0.003430738,0.0001031387,0.00006409216,0.00003470307,0.0006626509,0.00006100577,0.002707869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001374302,"threshold_uncertainty_score":0.004771888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032534010112333,"score_gpt":0.2511224694726181,"score_spread":0.2407971293714948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}