{"id":"W2037714333","doi":"10.1074/jbc.m111.336339","title":"Distant Cytosolic Residues Mediate a Two-way Molecular Switch That Controls the Modulation of Inwardly Rectifying Potassium (Kir) Channels by Cholesterol and Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2)","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Institutes of Health; Virginia Commonwealth University; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; American Heart Association","keywords":"Phosphatidylinositol 4,5-bisphosphate; Potassium channel; Gating; Ion channel; Chemistry; Cytosol; Phosphatidylinositol; Inward-rectifier potassium ion channel; Cell biology; Biophysics; Biochemistry; Biology; Signal transduction; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007406911,0.0002295456,0.0003419528,0.00002348641,0.000142409,0.00003714866,0.0002102352,0.0002902986,0.00002308499],"category_scores_gemma":[0.0002223014,0.0001438217,0.0001714479,0.00009611027,0.0001718338,0.00002465232,0.0001486412,0.0002365136,6.814557e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002878295,"about_ca_system_score_gemma":0.00002845445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006482366,"about_ca_topic_score_gemma":4.064412e-7,"domain_scores_codex":[0.9985139,0.0001205826,0.0005446188,0.0002253479,0.0002886994,0.0003068273],"domain_scores_gemma":[0.9986619,0.00006143494,0.0007059447,0.0002064023,0.0001806813,0.0001835807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000393681,0.00008943128,0.01019085,0.00002955896,0.00008917872,0.000001839359,0.0001114917,0.0001630331,0.9870856,0.00001217634,0.0002397521,0.001593415],"study_design_scores_gemma":[0.001260342,0.0002054233,0.007497607,0.00004480032,0.00004362492,0.0000865602,0.0001633127,0.000296462,0.987333,0.0001362096,0.002753591,0.0001790497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904797,0.005457537,0.002831226,0.000528485,0.0003961738,0.0001596087,0.00001942439,0.000008130073,0.0001197321],"genre_scores_gemma":[0.998212,0.00069286,0.0001047862,0.0002312517,0.0006000343,0.00001130304,0.00005590532,0.00001633702,0.00007548506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007732355,"threshold_uncertainty_score":0.5864878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01893171324501105,"score_gpt":0.2547045709194553,"score_spread":0.2357728576744443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}