{"id":"W2037714333","doi":"10.1074/jbc.m111.336339","title":"Distant Cytosolic Residues Mediate a Two-way Molecular Switch That Controls the Modulation of Inwardly Rectifying Potassium (Kir) Channels by Cholesterol and Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2)","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Institutes of Health; Virginia Commonwealth University; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; American Heart Association","keywords":"Phosphatidylinositol 4,5-bisphosphate; Potassium channel; Gating; Ion channel; Chemistry; Cytosol; Phosphatidylinositol; Inward-rectifier potassium ion channel; Cell biology; Biophysics; Biochemistry; Biology; Signal transduction; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001939935,0.0004811512,0.0003287882,0.0001003942,0.000208816,0.0004731693,0.0003021954,0.0004556329,0.001256141],"category_scores_gemma":[0.0002576325,0.0001113307,0.0003329393,0.00008410568,0.0004972978,0.00042939,0.0004157059,0.0006630342,0.0004547449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004138985,"about_ca_system_score_gemma":0.000238179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002346816,"about_ca_topic_score_gemma":0.0002533109,"domain_scores_codex":[0.9998046,0.00003230843,0.00002159187,0.00005126507,0.0000487453,0.00004161497],"domain_scores_gemma":[0.9997452,0.00005426108,0.00009742408,0.00002564274,0.0000187446,0.00005878845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000270124,0.00003990805,0.0004936958,0.00002895589,0.000008353877,0.0002441303,0.00001609285,0.000168681,0.9970048,0.0004415742,0.00003156364,0.001252161],"study_design_scores_gemma":[0.00007942778,0.0002202509,0.004320708,0.000009472093,0.00002678723,0.0008561568,0.00005844552,0.002797177,0.9901016,0.0002180814,0.001295863,0.0000160717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959458,0.0002903907,0.002855014,0.00006980639,0.00003855049,0.00001716643,0.00005090733,0.00004116056,0.0006912755],"genre_scores_gemma":[0.9970722,0.0002106866,0.001949258,0.00006142507,0.00001057624,0.0000150916,0.0001136201,0.00001063653,0.0005565333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001256141,"threshold_uncertainty_score":0.004202187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01893171324501105,"score_gpt":0.2547045709194553,"score_spread":0.2357728576744443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}