{"id":"W2037722651","doi":"10.1073/pnas.120161797","title":"The SOS response regulates adaptive mutation","year":2000,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":294,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Fondation pour la Recherche Médicale; National Institute of General Medical Sciences; U.S. Department of Defense","keywords":"Suppressor mutation; Mutation; SOS response; Adaptive mutation; Biology; Somatic hypermutation; Genetics; Adaptive response; DNA damage; DNA repair; Gene; Cell biology; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009963211,0.000336926,0.0001529933,0.000227349,0.0001502222,0.0003658081,0.0001389925,0.0001824698,0.0009286362],"category_scores_gemma":[0.0001518392,0.0001226655,0.0001255828,0.0001108424,0.0002355074,0.0001239631,0.0003465919,0.0003849193,0.000431424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003724811,"about_ca_system_score_gemma":0.0001889907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004073255,"about_ca_topic_score_gemma":0.0005546411,"domain_scores_codex":[0.9998587,0.000017201,0.000007419721,0.00002726328,0.00004727788,0.00004203001],"domain_scores_gemma":[0.9998339,0.00002071282,0.00004720521,0.00001236729,0.00003316108,0.00005257059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004771986,0.00000605191,0.0003444258,0.00001306744,0.000001232085,0.00004455635,0.000007193143,0.00002673359,0.9980937,0.00009818101,0.00002850554,0.001288661],"study_design_scores_gemma":[0.00001339424,0.0001083886,0.0239963,0.00001047863,0.000007569385,0.0004338671,0.0000428915,0.001076665,0.97056,0.0002642208,0.003475816,0.00001041727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878777,0.002583683,0.005660031,0.0001722007,0.00002960912,0.00003705283,0.0002768215,0.0002509645,0.003112029],"genre_scores_gemma":[0.995516,0.0007428597,0.00139688,0.00007529511,0.000007558718,0.000013858,0.0002962352,0.00003090536,0.001920411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009286362,"threshold_uncertainty_score":0.003106594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01998883917517925,"score_gpt":0.2803660639984725,"score_spread":0.2603772248232933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}