{"id":"W2037728003","doi":"10.1182/blood-2002-07-2108","title":"Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6","year":2003,"lang":"en","type":"article","venue":"Blood","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases","keywords":"DMT1; Mutant; Biochemistry; Transmembrane domain; Major facilitator superfamily; Chemistry; Transporter; Transport protein; Membrane transport protein; ATP-binding cassette transporter; Mutagenesis; Hereditary hemochromatosis; Mutation; Yeast; Iron-binding proteins; Transmembrane protein; Cell biology; Biology; Transferrin; Genetics; Amino acid; Gene; Receptor; Hemochromatosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002854583,0.000218534,0.0004904047,0.000120168,0.00003036127,0.000001987442,0.00007658691,0.0001743271,0.0003955084],"category_scores_gemma":[0.00001494935,0.0002066583,0.0001337923,0.0002991755,0.00009995326,0.00009289763,9.146506e-7,0.0001441708,0.000004665106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001327228,"about_ca_system_score_gemma":0.00007860916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001664461,"about_ca_topic_score_gemma":0.00007864207,"domain_scores_codex":[0.998448,0.00005089479,0.0005372365,0.0003163082,0.0003480281,0.000299578],"domain_scores_gemma":[0.9994739,0.00002078222,0.00008544791,0.0002668695,0.00003466742,0.000118331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005806573,0.004442519,0.1605192,0.001162917,0.00004702563,0.00004182043,0.002093805,0.00003279665,0.8260012,0.001614166,0.001786863,0.001677131],"study_design_scores_gemma":[0.0486215,0.0006319127,0.4224104,0.000260791,0.001371111,0.00007173141,0.0008227829,0.000007779727,0.4220899,0.0009550221,0.1018305,0.0009265494],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870079,0.004124731,0.0006730723,0.0002706203,0.00007923521,0.0004568442,0.00008739586,0.00004373038,0.007256438],"genre_scores_gemma":[0.9970008,0.0003679457,0.0008924565,0.0001254476,0.00002715197,0.00002154238,0.0003939388,0.00003747755,0.001133288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4039112,"threshold_uncertainty_score":0.8427281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005531337162986927,"score_gpt":0.2108703138585418,"score_spread":0.2053389766955549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}