{"id":"W2037728003","doi":"10.1182/blood-2002-07-2108","title":"Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6","year":2003,"lang":"en","type":"article","venue":"Blood","topic":"Iron Metabolism and Disorders","field":"Medicine","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases","keywords":"DMT1; Mutant; Biochemistry; Transmembrane domain; Major facilitator superfamily; Chemistry; Transporter; Transport protein; Membrane transport protein; ATP-binding cassette transporter; Mutagenesis; Hereditary hemochromatosis; Mutation; Yeast; Iron-binding proteins; Transmembrane protein; Cell biology; Biology; Transferrin; Genetics; Amino acid; Gene; Receptor; Hemochromatosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001013726,0.0002733915,0.0001510396,0.00009055353,0.00009983716,0.0001725563,0.0001399912,0.000184125,0.0006774457],"category_scores_gemma":[0.0001138747,0.00007723488,0.0001217246,0.00008835624,0.0001244645,0.0001178407,0.0001150966,0.000216445,0.0002917592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003193357,"about_ca_system_score_gemma":0.00009887967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004373087,"about_ca_topic_score_gemma":0.0003772948,"domain_scores_codex":[0.9999475,0.00001190825,0.000005299618,0.00001217135,0.00001229518,0.00001088707],"domain_scores_gemma":[0.9999446,0.000007854174,0.00002167495,0.000005119156,0.000006460798,0.00001429815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000121626,0.000008284525,0.0004079572,0.00001236299,0.0000022359,0.00007367451,0.000006562349,0.000047056,0.9987689,0.00003575546,0.00002355756,0.0004920476],"study_design_scores_gemma":[0.00003146484,0.0001346826,0.006295682,0.000003763703,0.00001121654,0.001260559,0.00002247325,0.001150468,0.9895281,0.00003659501,0.00152096,0.00000394347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980984,0.0004344591,0.0009286075,0.00004993221,0.000007021825,0.000006335383,0.0001100049,0.00002270123,0.0003425846],"genre_scores_gemma":[0.9972116,0.0002472622,0.001344678,0.00002479478,0.000004690695,0.000006670669,0.0003797943,0.00001274764,0.0007678395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006774457,"threshold_uncertainty_score":0.002316952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005531337162986927,"score_gpt":0.2108703138585418,"score_spread":0.2053389766955549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}