{"id":"W2037740736","doi":"10.1310/hct1304-179","title":"A Pilot, Prospective, Open-Label Simplification Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Once-Daily Lopinavir-Ritonavir Monotherapy in HIV-HCV Coinfected Patients: The MONOCO Study","year":2012,"lang":"en","type":"article","venue":"HIV Clinical Trials","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of British Columbia; Ottawa Hospital; Abbott (Canada); University of Ottawa","funders":"Ontario HIV Treatment Network; Abbott Laboratories","keywords":"Medicine; Ritonavir; Lopinavir; Adverse effect; Pharmacokinetics; Prospective cohort study; Lopinavir/ritonavir; Internal medicine; Viral load; Pharmacology; Gastroenterology; Human immunodeficiency virus (HIV); Antiretroviral therapy; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01368224,0.0003538952,0.001413547,0.0001116318,0.0001783129,0.00006125656,0.0004174004,0.00006139306,0.00006172153],"category_scores_gemma":[0.004106241,0.0001860423,0.0000931865,0.000606697,0.0001495054,0.0001122232,0.0002566243,0.0003796385,0.00008262584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001314661,"about_ca_system_score_gemma":0.0001612567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006904631,"about_ca_topic_score_gemma":0.00005313669,"domain_scores_codex":[0.9918846,0.004068442,0.002484872,0.0005699754,0.0006101897,0.000381894],"domain_scores_gemma":[0.9924791,0.005712644,0.0005431353,0.0007359217,0.0002962397,0.0002330003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01250022,0.04787905,0.9018008,0.00001227248,0.0007750353,0.000003070793,0.006284233,0.000004929896,0.0001336641,0.00004504228,0.001656683,0.02890498],"study_design_scores_gemma":[0.09507014,0.006025149,0.8935567,0.00009046992,0.0008022522,8.198971e-7,0.00113972,0.00007779877,0.0001183437,0.00003718128,0.002882065,0.0001993203],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971732,0.000191452,0.00005488974,0.003267955,0.0003183443,0.02396548,0.00004483271,0.00003472205,0.0003903173],"genre_scores_gemma":[0.9968289,0.0002468245,0.0003884437,0.0004092228,0.000255409,0.001030305,0.00003970823,0.00004349657,0.0007577568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08256991,"threshold_uncertainty_score":0.7586586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2869704247703874,"score_gpt":0.5185631127525557,"score_spread":0.2315926879821684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}