{"id":"W2037740736","doi":"10.1310/hct1304-179","title":"A Pilot, Prospective, Open-Label Simplification Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Once-Daily Lopinavir-Ritonavir Monotherapy in HIV-HCV Coinfected Patients: The MONOCO Study","year":2012,"lang":"en","type":"article","venue":"HIV Clinical Trials","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of British Columbia; Ottawa Hospital; Abbott (Canada); University of Ottawa","funders":"Ontario HIV Treatment Network; Abbott Laboratories","keywords":"Medicine; Ritonavir; Lopinavir; Adverse effect; Pharmacokinetics; Prospective cohort study; Lopinavir/ritonavir; Internal medicine; Viral load; Pharmacology; Gastroenterology; Human immunodeficiency virus (HIV); Antiretroviral therapy; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004062824,0.001572813,0.002110868,0.0004515542,0.0008003612,0.0007367324,0.0007730647,0.000985457,0.00330652],"category_scores_gemma":[0.003130522,0.0007301185,0.001246649,0.0003482699,0.001276351,0.0008840477,0.0007681487,0.001575665,0.0006520306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00076144,"about_ca_system_score_gemma":0.001359567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001046522,"about_ca_topic_score_gemma":0.001461647,"domain_scores_codex":[0.99806,0.001197491,0.0001026667,0.0002152972,0.0002051105,0.0002193192],"domain_scores_gemma":[0.9960017,0.0007626255,0.00113989,0.0005630699,0.0003101463,0.001222702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8025727,0.1190608,0.02854282,0.0004124735,0.0009174214,0.0002491358,0.0006431154,0.0007006129,0.01539719,0.0001242321,0.0009228836,0.03045668],"study_design_scores_gemma":[0.2348762,0.7257382,0.03625377,0.00001351588,0.0003217952,0.0001329408,0.00007912628,0.0005916052,0.00105281,0.00007999191,0.0008267727,0.0000331607],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962603,0.0001906446,0.0003310299,0.00007174807,0.00002649658,0.002511241,0.000207564,0.00001874787,0.0003822721],"genre_scores_gemma":[0.992274,0.0002314347,0.001725713,0.0003416129,0.0001735448,0.00369188,0.0007154093,0.00001103373,0.0008353182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004062824,"threshold_uncertainty_score":0.02148658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2869704247703874,"score_gpt":0.5185631127525557,"score_spread":0.2315926879821684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}