{"id":"W2037787006","doi":"10.1038/ncb1113","title":"PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3","year":2004,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":366,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"","keywords":"Protein kinase B; Cell biology; PI3K/AKT/mTOR pathway; Signal transduction; AKT1; Transforming growth factor; Activator (genetics); Phosphorylation; Biology; Growth factor; Kinase; Transcription factor; Chemistry; Biochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008200667,0.0002602699,0.0002128403,0.00004877749,0.0001061534,0.00002276951,0.0002438262,0.0006519358,0.00003559047],"category_scores_gemma":[0.00006668941,0.0002061898,0.0001014485,0.000115142,0.000122817,0.000007806366,0.00007822033,0.0003913377,0.00002749937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003626836,"about_ca_system_score_gemma":0.0001108901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003619974,"about_ca_topic_score_gemma":0.00004686476,"domain_scores_codex":[0.9987219,0.00006838989,0.0001988159,0.0005845612,0.00008556399,0.0003407784],"domain_scores_gemma":[0.9993328,0.00003513013,0.0001282575,0.0003185509,0.0001115432,0.0000736464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003194214,0.0001469841,0.00110916,0.00002834296,0.00009388987,0.00001147178,0.00008221492,0.005007685,0.9923501,0.0001035133,0.0002505456,0.0004966977],"study_design_scores_gemma":[0.0008078442,0.0005121939,0.0001703838,0.00003692302,0.00003835384,0.00001625825,0.0000488696,0.00001997299,0.95143,0.0003771821,0.04624427,0.0002978047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860986,0.006392196,0.002319935,0.0001242959,0.000384739,0.0001965505,0.00002273237,0.00006849928,0.004392392],"genre_scores_gemma":[0.9952443,0.00009623437,0.0028898,0.0006297475,0.000438882,0.00002498998,0.0004369435,0.00003882106,0.0002003164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04599373,"threshold_uncertainty_score":0.8408177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005687106103401496,"score_gpt":0.2496104459186818,"score_spread":0.2439233398152803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}