{"id":"W2037793441","doi":"10.1126/scisignal.2000576","title":"Regulation of Epidermal Growth Factor Receptor Trafficking by Lysine Deacetylase HDAC6","year":2009,"lang":"en","type":"article","venue":"Science Signaling","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":180,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"HDAC6; Acetylation; Cell biology; Epidermal growth factor receptor; Histone deacetylase; Biology; HDAC4; Growth factor receptor; Receptor; Chemistry; Biochemistry; Signal transduction; Histone; Histone methyltransferase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008926452,0.0002011656,0.0001554401,0.0001155622,0.0001049985,0.0002859238,0.0001461843,0.00009925575,0.0007988072],"category_scores_gemma":[0.0001004312,0.00009642498,0.0001966674,0.00008585423,0.0001199799,0.0001207049,0.0001130179,0.0002026072,0.000347521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002053475,"about_ca_system_score_gemma":0.0001014721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005356304,"about_ca_topic_score_gemma":0.00129658,"domain_scores_codex":[0.9999357,0.000008945922,0.000004577394,0.00001719399,0.00001780574,0.00001578448],"domain_scores_gemma":[0.999956,0.000006791689,0.00001331363,0.000005279348,0.00000838836,0.00001017106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001494387,0.00001099577,0.001421594,0.00002642466,0.00001001373,0.00003582205,0.000006822325,0.00008987833,0.9946293,0.0001179163,0.00006725397,0.003434643],"study_design_scores_gemma":[0.00001948048,0.0001203736,0.02113399,0.000003397954,0.00001949258,0.0002083331,0.00002578376,0.002217971,0.9734867,0.0001069527,0.002653108,0.000004433357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916893,0.002663051,0.003539759,0.0001009539,0.00003527812,0.00001165213,0.000325808,0.00007947355,0.00155484],"genre_scores_gemma":[0.9959767,0.001066562,0.001431645,0.00002770225,0.000006092235,0.00000451325,0.0002651395,0.00001097996,0.001210692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007988072,"threshold_uncertainty_score":0.002672315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01239924478700193,"score_gpt":0.2809492914686546,"score_spread":0.2685500466816527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}