{"id":"W2037793441","doi":"10.1126/scisignal.2000576","title":"Regulation of Epidermal Growth Factor Receptor Trafficking by Lysine Deacetylase HDAC6","year":2009,"lang":"en","type":"article","venue":"Science Signaling","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":180,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"HDAC6; Acetylation; Cell biology; Epidermal growth factor receptor; Histone deacetylase; Biology; HDAC4; Growth factor receptor; Receptor; Chemistry; Biochemistry; Signal transduction; Histone; Histone methyltransferase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007387659,0.0001368539,0.0001537959,0.0001490325,0.0002262728,0.00004079102,0.0003559227,0.00009350976,0.00005669374],"category_scores_gemma":[0.0005057448,0.000134435,0.00008035196,0.000567744,0.0003879047,0.00002722634,0.00005287045,0.0001097852,0.00001089437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006010298,"about_ca_system_score_gemma":0.0002354337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001419092,"about_ca_topic_score_gemma":0.000001557228,"domain_scores_codex":[0.9981902,0.00006588267,0.0003034834,0.0004649204,0.0005612841,0.00041427],"domain_scores_gemma":[0.9991171,0.00002097262,0.0001308789,0.0002696341,0.0003087938,0.000152653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003057127,0.00004728536,0.00006829914,0.000007469775,0.000003767563,5.37553e-7,0.0001107254,0.0002775476,0.9948622,0.00004407965,0.001309211,0.00323828],"study_design_scores_gemma":[0.0002460327,0.0002210126,0.0004036038,0.00002752114,0.000003436772,0.000004231814,0.00004720355,0.0004745672,0.9977244,0.00002251392,0.0006730105,0.0001525333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961229,0.0002561607,0.002738073,0.0002634785,0.0001183435,0.0001411161,0.00001761484,0.00001791909,0.0003244164],"genre_scores_gemma":[0.9976853,0.00001464909,0.001755263,0.00007502032,0.0002015268,0.000002856774,0.00004428075,0.00001115573,0.0002099988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003085747,"threshold_uncertainty_score":0.5482101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01239924478700193,"score_gpt":0.2809492914686546,"score_spread":0.2685500466816527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}