{"id":"W2037802239","doi":"10.1111/j.1365-2222.2006.02370.x","title":"Signal transducer and activator of transcription 6 down‐regulates toll‐like receptor‐4 expression of a monocytic cell line","year":2006,"lang":"en","type":"article","venue":"Clinical & Experimental Allergy","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Christie (Canada)","funders":"","keywords":"TLR4; Toll-like receptor; STAT protein; Molecular biology; Transfection; Biology; Receptor; STAT6; Lipopolysaccharide; Transcription factor; Signal transduction; Cell biology; STAT3; Cell culture; Innate immune system; Immunology; Interleukin 4; Cytokine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002217054,0.0001745705,0.0004298465,0.00006755264,0.00006396184,0.000005034705,0.0001158618,0.0003326833,0.0009735656],"category_scores_gemma":[0.000009251482,0.0001482855,0.0002378617,0.00006065225,0.0003360731,0.0001402979,0.00003405448,0.0001645107,0.00002378926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000214373,"about_ca_system_score_gemma":0.00003446181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008804402,"about_ca_topic_score_gemma":0.000002570276,"domain_scores_codex":[0.9983215,0.0002914369,0.0008725832,0.0002708206,0.00005397777,0.0001896256],"domain_scores_gemma":[0.9993204,0.0001881327,0.0002477661,0.0001778144,0.00004176025,0.00002415239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002429858,0.0008470762,0.00006779152,0.0000240371,0.0000634325,6.562137e-7,0.0004312408,0.0000148547,0.9938812,0.0000992487,0.000636766,0.001503799],"study_design_scores_gemma":[0.003004754,0.0009613697,0.001349351,0.00007249481,0.00001935382,0.00000444946,0.0003951002,0.00001827059,0.9865954,0.00004802009,0.007384986,0.0001464374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912032,0.007691838,0.0001362376,0.00006487261,0.0003263332,0.0002024628,0.00001032487,0.0000254142,0.0003393396],"genre_scores_gemma":[0.9983624,0.0002781397,0.0002092612,0.00002734121,0.00004667552,0.00001685221,0.0001124573,0.00001595833,0.0009309597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007413699,"threshold_uncertainty_score":0.9999397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01789732447604036,"score_gpt":0.279606648797725,"score_spread":0.2617093243216846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}