{"id":"W2037811978","doi":"10.1002/anie.201408641","title":"A Bio‐Inspired Total Synthesis of Tetrahydrofuran Lignans","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; McGill University","keywords":"Lignan; Pinoresinol; Oxidative coupling of methane; Ferulic acid; Total synthesis; Phenols; Chemistry; Propenyl; Tetrahydrofuran; Biomimetic synthesis; Broad spectrum; Stereochemistry; Combinatorial chemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009421298,0.000433579,0.000228545,0.0002850852,0.0001971378,0.0002538055,0.0003205876,0.0002913501,0.001677915],"category_scores_gemma":[0.00007143257,0.0001573183,0.0003097122,0.0003588933,0.0001917684,0.0003582799,0.0003588362,0.000546346,0.0006508075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003340365,"about_ca_system_score_gemma":0.0004093698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005332278,"about_ca_topic_score_gemma":0.001141884,"domain_scores_codex":[0.9999298,0.000007401829,0.000003593841,0.0000164656,0.00001632639,0.00002639973],"domain_scores_gemma":[0.9999738,0.000003350008,0.000006268745,0.000005063201,0.000003923835,0.00000750335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003463129,0.00004742067,0.0000687615,0.0002069832,0.0000205407,0.0002435864,0.00007534557,0.002020099,0.9635956,0.00608674,0.0004044092,0.02719587],"study_design_scores_gemma":[0.00002515153,0.0003664341,0.000521224,0.00002169977,0.00002722521,0.0003819254,0.00003199072,0.002779144,0.9635431,0.001787714,0.03048508,0.00002923567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7527226,0.01151439,0.179873,0.0007882673,0.0004356718,0.0002804166,0.00168276,0.001048599,0.0516544],"genre_scores_gemma":[0.9308161,0.006835123,0.05047417,0.0001403104,0.00003187774,0.0001219709,0.000588001,0.00006750326,0.01092494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001677915,"threshold_uncertainty_score":0.005613148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01741482165102744,"score_gpt":0.2423371069407709,"score_spread":0.2249222852897435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}