{"id":"W2037811978","doi":"10.1002/anie.201408641","title":"A Bio‐Inspired Total Synthesis of Tetrahydrofuran Lignans","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; McGill University","keywords":"Lignan; Pinoresinol; Oxidative coupling of methane; Ferulic acid; Total synthesis; Phenols; Chemistry; Propenyl; Tetrahydrofuran; Biomimetic synthesis; Broad spectrum; Stereochemistry; Combinatorial chemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001784833,0.000134937,0.0001453403,0.00006162161,0.00002776379,0.00001787973,0.0001800351,0.0001422398,0.00004368931],"category_scores_gemma":[0.0002601809,0.0001246122,0.0001151616,0.00006108552,0.00008036996,0.00001731735,0.00005736486,0.00005396425,0.00001104783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000364911,"about_ca_system_score_gemma":0.00007164627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005452783,"about_ca_topic_score_gemma":0.00001657853,"domain_scores_codex":[0.9991021,0.0000249039,0.0002094196,0.0002492932,0.0002718081,0.0001425418],"domain_scores_gemma":[0.9993914,0.00003198229,0.0001377545,0.0001679561,0.0001804974,0.0000904297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001235182,0.0001453111,0.000874277,0.00001005128,0.00009637132,0.000003593881,0.00003676929,0.000008431283,0.9894251,0.00002881201,0.007803975,0.001443789],"study_design_scores_gemma":[0.00031139,0.00008754747,0.001302192,0.00004238845,0.0000236661,0.00003275507,0.00009731254,0.00003036373,0.9895615,0.00007151687,0.008290702,0.0001486393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824662,0.0001381348,0.001694071,0.0005854851,0.0008036281,0.0001095498,0.0005229213,0.00002469419,0.01365529],"genre_scores_gemma":[0.9979453,0.00007306175,0.000281722,0.00007272928,0.0008886259,0.00002926172,0.0004426777,0.00001379859,0.0002528041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0154791,"threshold_uncertainty_score":0.5081538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01741482165102744,"score_gpt":0.2423371069407709,"score_spread":0.2249222852897435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}