{"id":"W2037822148","doi":"10.1016/j.bpj.2009.12.4195","title":"pH Modulation of the Cardiac Voltage Gated Sodium Channel, Nav1.5","year":2010,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Sodium channel; Chemistry; Xenopus; Depolarization; Kinetics; Conductance; Membrane potential; Biophysics; Extracellular; Sodium; Time constant; Voltage clamp; Patch clamp; Reversal potential; Internal medicine; Analytical Chemistry (journal); Biochemistry; Chromatography; Medicine; Biology; Receptor; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382586,0.0001315609,0.000145912,0.00008566572,0.0001115256,0.0003331279,0.0001987294,0.0003603346,0.002253731],"category_scores_gemma":[0.0004037363,0.0001082467,0.0001350824,0.00005383307,0.0002432758,0.0004662066,0.0002392293,0.0003111879,0.0002582466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001761847,"about_ca_system_score_gemma":0.00009141699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002016374,"about_ca_topic_score_gemma":0.0001602917,"domain_scores_codex":[0.9999012,0.00002204478,0.000005531906,0.00001719559,0.00002448704,0.00002959622],"domain_scores_gemma":[0.999922,0.00003106571,0.00001366595,0.000007620956,0.00001054902,0.00001509578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001225222,0.0000270923,0.0004739399,0.00007613644,0.00001015707,0.0001557997,0.00006517091,0.0001589691,0.9922407,0.0005341723,0.000174359,0.004858335],"study_design_scores_gemma":[0.000309891,0.001399628,0.04586953,0.00004779913,0.00005532801,0.001912537,0.0003331474,0.008268991,0.9344563,0.00208206,0.005235152,0.00002957205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989824,0.003572611,0.001579357,0.0005244633,0.0001187141,0.00001194334,0.0001300206,0.00003220869,0.004206687],"genre_scores_gemma":[0.9982575,0.0007455544,0.0001811158,0.0001101826,0.00002826529,0.000003377347,0.00005356265,0.000005561819,0.0006148255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002253731,"threshold_uncertainty_score":0.007539511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007583068569089177,"score_gpt":0.2407159107718492,"score_spread":0.23313284220276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}