{"id":"W2037837789","doi":"10.1016/j.carres.2004.08.008","title":"Intramolecular aldol cyclization of C-4-ulopyranosyl-2′-oxoalkanes controlled by steric effects. Asymmetric synthesis of substituted 8-oxabicyclo[3.2.1]octanones and -octenones and cyclopentenones","year":2004,"lang":"en","type":"article","venue":"Carbohydrate Research","topic":"Traditional and Medicinal Uses of Annonaceae","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences; National Research Council Canada","funders":"National Research Council Canada; National Science Council","keywords":"Chemistry; Aldol reaction; Intramolecular force; Steric effects; Aldehyde; Cyclopentenone; Stereochemistry; Aldol condensation; Enol; Medicinal chemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000183736,0.0005823564,0.0002032653,0.0002715344,0.0002868172,0.0002891501,0.0003034915,0.0002418564,0.002752919],"category_scores_gemma":[0.0001360964,0.0001696047,0.0002378885,0.0002493654,0.0002850767,0.0004653308,0.0003253856,0.0005151748,0.0007249166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002924984,"about_ca_system_score_gemma":0.0004377158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000503226,"about_ca_topic_score_gemma":0.001280666,"domain_scores_codex":[0.9998546,0.00002719155,0.000008542178,0.00002144863,0.00001317718,0.00007497245],"domain_scores_gemma":[0.9999408,0.000008462322,0.00001463215,0.000008027069,0.000007542906,0.00002060623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005122907,0.0002571198,0.0003305671,0.0004191304,0.00003533434,0.0009827201,0.0004871108,0.001467425,0.9529544,0.01066557,0.0007884282,0.03109981],"study_design_scores_gemma":[0.00008686217,0.0008426489,0.001196731,0.00002350181,0.00003168863,0.000405273,0.0001198656,0.001125397,0.9771041,0.0009740504,0.01805512,0.00003464922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9452988,0.004399459,0.01299106,0.000365566,0.0003413714,0.0001781574,0.0003293068,0.0001838903,0.03591241],"genre_scores_gemma":[0.9889405,0.001918522,0.00297901,0.00008209604,0.00003073972,0.00004852437,0.0001478476,0.00002623212,0.005826469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002752919,"threshold_uncertainty_score":0.009209454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087887816197913,"score_gpt":0.2765202081427836,"score_spread":0.2656413299808045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}