{"id":"W2037848967","doi":"10.1074/jbc.m113.523266","title":"Structure of the Toxoplasma gondii ROP18 Kinase Domain Reveals a Second Ligand Binding Pocket Required for Acute Virulence","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Virulence; Toxoplasma gondii; Biology; Population; Protein kinase domain; Virulence factor; Intracellular parasite; Kinase; Genetics; Cell biology; Intracellular; Gene; Medicine; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003537289,0.0002331093,0.0006080605,0.00004406501,0.0002163712,0.00002287045,0.0007000311,0.0004969229,0.001121151],"category_scores_gemma":[0.001177388,0.000122625,0.0003268052,0.0001633051,0.0006360071,0.0001036502,0.0002766863,0.0006566944,0.00001327452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007114444,"about_ca_system_score_gemma":0.00008562203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000198765,"about_ca_topic_score_gemma":0.000001238592,"domain_scores_codex":[0.9983773,0.0001444014,0.0006887082,0.0002396488,0.00008913293,0.0004608718],"domain_scores_gemma":[0.9979194,0.0006495223,0.0007495833,0.0002687413,0.0003494818,0.00006327334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002983011,0.00005976658,0.001950036,0.00006644831,0.0004189892,0.000007818756,0.0001342127,6.979677e-7,0.9895874,0.00002291366,0.007182226,0.0002711966],"study_design_scores_gemma":[0.001241272,0.0002741401,0.004936685,0.0001078307,0.00004793078,0.0004016166,0.0003823809,3.098116e-7,0.9873314,0.002838183,0.002291736,0.0001465103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996691,0.001514217,0.00001478454,0.0006002736,0.0002717493,0.0002887249,0.0004806553,0.00001063186,0.0001279583],"genre_scores_gemma":[0.9980181,0.0001271456,0.0006135569,0.00008902496,0.0001037942,0.00001208113,0.00001797531,0.00001046481,0.001007823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00489049,"threshold_uncertainty_score":0.999792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01770699511354786,"score_gpt":0.2719567845281288,"score_spread":0.254249789414581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}