{"id":"W2037899769","doi":"10.1016/j.nbd.2005.04.001","title":"Denervation and repeated l-DOPA induce complex regulatory changes in neurochemical phenotypes of striatal neurons: Implication of a dopamine D1-dependent mechanism","year":2005,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Parkinson Society Canada","keywords":"Neurochemical; Dopamine; Neuroscience; Denervation; Mechanism (biology); Dopaminergic; Phenotype; Chemistry; Psychology; Biology; Endocrinology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002077418,0.0006094292,0.001121559,0.0003476136,0.0002678079,0.000418921,0.0004507541,0.0006687075,0.00149871],"category_scores_gemma":[0.0002850284,0.0003866341,0.0008478998,0.0002402964,0.0008198771,0.0004362227,0.0003561533,0.001393113,0.0002639666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007713693,"about_ca_system_score_gemma":0.0003920057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001769204,"about_ca_topic_score_gemma":0.007345716,"domain_scores_codex":[0.999652,0.00003949364,0.00003296018,0.00008768533,0.00006326105,0.0001244738],"domain_scores_gemma":[0.9996688,0.00005554557,0.00008422197,0.00007289917,0.00002566754,0.00009279821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00114679,0.0001029666,0.0003025,0.00003098477,0.00002794072,0.0001253356,0.00002982051,0.00004500413,0.9971379,0.00005031646,0.00003506811,0.0009652445],"study_design_scores_gemma":[0.000108106,0.003364459,0.04066915,0.00001237334,0.00008770148,0.000639058,0.0002032244,0.0008598924,0.95317,0.0001474627,0.00071097,0.00002755705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976124,0.0008069608,0.0006968366,0.00006555815,0.0000446232,0.00002608273,0.0001995459,0.00003488056,0.000513323],"genre_scores_gemma":[0.9959412,0.0004289492,0.0008838371,0.000104887,0.00002110021,0.00007793796,0.0003043141,0.00002803571,0.002209755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001769204,"threshold_uncertainty_score":0.005596757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05050045147577051,"score_gpt":0.3168222022170076,"score_spread":0.2663217507412371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}