{"id":"W2037901495","doi":"10.1152/ajpgi.00358.2011","title":"Epidermal growth factor receptor transactivation is required for proteinase-activated receptor-2-induced COX-2 expression in intestinal epithelial cells","year":2012,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Epidermal growth factor receptor; MAPK/ERK pathway; LY294002; Epidermal growth factor; Cancer research; Tyrosine kinase; Tyrosine phosphorylation; Biology; Receptor tyrosine kinase; Autocrine signalling; Phosphorylation; Molecular biology; Signal transduction; Protein kinase B; Cell biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004378913,0.0004280784,0.001144391,0.0002967922,0.0001168879,0.000008334075,0.0001645369,0.0001136542,0.0001482982],"category_scores_gemma":[0.0004103817,0.00032873,0.0002576801,0.0002669205,0.0004956108,0.0003959565,0.00004137216,0.0006980022,0.00001447248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001287929,"about_ca_system_score_gemma":0.0001820848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007276719,"about_ca_topic_score_gemma":8.19187e-7,"domain_scores_codex":[0.997317,0.000491587,0.0008030526,0.0004009552,0.0002113926,0.0007760432],"domain_scores_gemma":[0.9972292,0.0007178687,0.001021602,0.0001856118,0.0004275632,0.0004181982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008310092,0.0004711838,0.002919434,0.0002065128,0.00005551456,0.000008047636,0.0008454063,0.000003430996,0.9830341,0.00002539659,0.0002695015,0.00385136],"study_design_scores_gemma":[0.002838142,0.009484159,0.1369665,0.0006153092,0.00005845965,0.0004512107,0.0003858646,0.0001123681,0.8485259,0.0001032746,0.0001735094,0.0002853468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975569,0.00005949784,0.001034444,0.0003056882,0.0002992653,0.0006783024,0.00003132325,0.00002754482,0.000007020199],"genre_scores_gemma":[0.9860935,0.0000405971,0.01216983,0.0004071294,0.001149871,0.00005266213,0.00002672613,0.00004649875,0.00001314679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1345083,"threshold_uncertainty_score":0.9999165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01692127922461716,"score_gpt":0.2528788583752103,"score_spread":0.2359575791505932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}