{"id":"W2037908858","doi":"10.1042/cs20070220","title":"Familial combined hyperlipidaemia: how can genetic disorders be common, complex and comprehensible?","year":2007,"lang":"en","type":"letter","venue":"Clinical Science","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Phenotype; Disease; Complex disease; Clinical phenotype; Genetics; Biology; Gene; Underpinning; Bioinformatics; Computational biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":{"n_in":0,"stratum":"aff_core","weight":5595.2375,"opus":{"tier":"OUT","genre":"editorial/commentary","about_ca":false,"confidence":"high","reason":"Commentary proposing a disease model of familial combined hyperlipidaemia; a clinical-genetics topic."},"gpt":{"tier":"OUT","genre":"editorial/commentary","about_ca":false,"confidence":"high","reason":"It is a letter discussing familial hyperlipidaemia biology, not research itself."},"grok":{"tier":"OUT","genre":"editorial/commentary","about_ca":false,"confidence":"high","reason":"Letter proposing a multi-gene model of familial combined hyperlipidaemia; clinical commentary, not metaresearch."}},"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003226019,0.001026147,0.00201334,0.001187316,0.001744681,0.002977275,0.00178207,0.02086967,0.002283592],"category_scores_gemma":[0.02482422,0.0006029214,0.0006768055,0.0007301436,0.00569646,0.00985121,0.001982623,0.0203162,0.002134254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002336371,"about_ca_system_score_gemma":0.00117648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001806469,"about_ca_topic_score_gemma":0.002046986,"domain_scores_codex":[0.9981773,0.0008069093,0.0002486545,0.0002414494,0.0003566519,0.0001689976],"domain_scores_gemma":[0.992202,0.005544708,0.0004405862,0.0003882642,0.0009431263,0.0004812272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005276026,0.0002037623,0.01123186,0.000901037,0.00016346,0.1359015,0.002946419,0.0009614375,0.002259504,0.05801095,0.6418598,0.1450326],"study_design_scores_gemma":[0.0004744264,0.0002967565,0.007313317,0.001508459,0.0001409991,0.2859134,0.004166526,0.00362482,0.0007273514,0.2952009,0.4003536,0.0002794575],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002857361,0.008956325,0.000776895,0.9787664,0.006351312,0.00001375167,0.00002058932,0.00004836929,0.002208835],"genre_scores_gemma":[0.05772373,0.02431064,0.002812747,0.7880478,0.1233703,0.00007827506,0.00005679906,0.00004580275,0.003553844],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02086967,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07181342153349325,"score_gpt":0.3537321190169643,"score_spread":0.281918697483471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}