{"id":"W2037914683","doi":"10.1093/emboj/21.1.93","title":"LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin‐dependent degradation","year":2002,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute","keywords":"NUMB; Ubiquitin ligase; PDZ domain; RING finger domain; Ring finger; Biology; Ubiquitin; Ubiquitin-Protein Ligases; Cell biology; Mutant; DNA ligase; Degron; Proteasome; Biochemistry; Zinc finger; Transcription factor; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007484755,0.0002050177,0.0001421299,0.00003813268,0.0008829584,0.0001648116,0.0004104892,0.0001021977,0.0003033874],"category_scores_gemma":[0.0001240561,0.000124443,0.0001835427,0.00007463345,0.00007116883,0.0000142634,0.0001161672,0.000323172,0.0001504376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002932029,"about_ca_system_score_gemma":0.00006045321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001207769,"about_ca_topic_score_gemma":0.00002774043,"domain_scores_codex":[0.9986678,0.0001697747,0.0002760554,0.0002376678,0.0002260208,0.0004226649],"domain_scores_gemma":[0.9990624,0.00006087359,0.0002435109,0.0003607665,0.0001488318,0.0001236503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000389936,0.0002284283,0.000358321,0.00005441261,0.0001544766,0.00004437938,0.001277561,0.0002385728,0.9548557,0.0002367309,0.01654547,0.02561602],"study_design_scores_gemma":[0.0007518491,0.0005109143,0.0001317502,0.00003349031,0.00008458144,0.0008614958,0.0006853006,0.0006978663,0.9373012,0.0004960967,0.05821645,0.0002290448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855768,0.002738259,0.002746137,0.001269362,0.0006736432,0.0004964319,0.00003406343,0.00001893175,0.006446365],"genre_scores_gemma":[0.9886807,0.0007103496,0.0002636202,0.0005772036,0.001026324,0.00004545828,0.00002966142,0.00003757581,0.008629103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04167098,"threshold_uncertainty_score":0.6791092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03332213934788227,"score_gpt":0.2555637927320216,"score_spread":0.2222416533841394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}