{"id":"W2037914683","doi":"10.1093/emboj/21.1.93","title":"LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin‐dependent degradation","year":2002,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute","keywords":"NUMB; Ubiquitin ligase; PDZ domain; RING finger domain; Ring finger; Biology; Ubiquitin; Ubiquitin-Protein Ligases; Cell biology; Mutant; DNA ligase; Degron; Proteasome; Biochemistry; Zinc finger; Transcription factor; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002312519,0.0004147308,0.0003563489,0.0002835539,0.0005476009,0.0009833932,0.0003860375,0.0003704316,0.002453704],"category_scores_gemma":[0.0002827891,0.0002175766,0.0001856797,0.0002047276,0.0005446211,0.0008021367,0.0007004067,0.0003866282,0.002170081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001132423,"about_ca_system_score_gemma":0.0002487067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005088814,"about_ca_topic_score_gemma":0.0009900479,"domain_scores_codex":[0.9999033,0.00001650922,0.000005999767,0.00002779185,0.00002823034,0.00001810576],"domain_scores_gemma":[0.9998571,0.0000187344,0.00003683836,0.00002138494,0.00001718746,0.00004884713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000155082,0.00001520939,0.001398607,0.00005440731,0.000006974457,0.0003209509,0.00002989982,0.0002954715,0.9874148,0.001547928,0.0003734041,0.008387212],"study_design_scores_gemma":[0.00001179389,0.00004393668,0.00381858,0.000005881248,0.000009417391,0.0008615133,0.00004498394,0.00225561,0.9831452,0.0003614083,0.009433932,0.000007716687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9515395,0.007326488,0.02951648,0.000431615,0.0001374837,0.00002289809,0.0003396854,0.0008544129,0.009831512],"genre_scores_gemma":[0.9614149,0.001702564,0.007527709,0.00008743535,0.00002435418,0.00001868885,0.0004385713,0.00007793426,0.02870784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002453704,"threshold_uncertainty_score":0.008216381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03332213934788227,"score_gpt":0.2555637927320216,"score_spread":0.2222416533841394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}