{"id":"W2037918682","doi":"10.1038/nm.3372","title":"Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin","year":2013,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":875,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McMaster University","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"AMPK; Metformin; Lipogenesis; Glucose homeostasis; Endocrinology; Internal medicine; AMP-activated protein kinase; Insulin resistance; Type 2 diabetes; Fatty liver; Fatty acid synthesis; Protein kinase A; Acetyl-CoA carboxylase; Fatty acid synthase; Energy homeostasis; Lipid metabolism; Chemistry; Biology; Phosphorylation; Insulin; Fatty acid; Pyruvate carboxylase; Diabetes mellitus; Biochemistry; Medicine; Enzyme; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003031886,0.0001121502,0.0002462462,0.00005212755,0.00003004776,0.000008238899,0.00005754014,0.0001983348,0.000009275537],"category_scores_gemma":[0.000472589,0.0000674606,0.0000223885,0.0001176743,0.0002055027,0.000007308181,0.0000495162,0.0001599358,3.793486e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005746308,"about_ca_system_score_gemma":0.00001104606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005457667,"about_ca_topic_score_gemma":0.00003493047,"domain_scores_codex":[0.9993388,0.00006265623,0.0001696354,0.0001837684,0.0001147133,0.0001303969],"domain_scores_gemma":[0.9995232,0.0001022612,0.00008962611,0.0001656258,0.00007675357,0.00004251291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001121316,0.00001710152,0.0007951849,0.0001203115,0.00003821505,0.000001168806,0.0004608684,8.144227e-7,0.5090636,0.0001245361,0.0008617713,0.4884043],"study_design_scores_gemma":[0.004577278,0.0002320994,0.02649892,0.0001578479,0.00008069484,0.000009242088,0.0002117249,0.0001030827,0.9407275,0.000634651,0.02662193,0.0001450812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6042244,0.3952224,0.000007847098,0.000189786,0.0000992872,0.0001732998,0.000001149233,0.000002376613,0.00007950368],"genre_scores_gemma":[0.9462537,0.05254021,0.000138159,0.0007153283,0.0002747489,0.00001325508,0.00002512694,0.000009903025,0.00002961623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4882592,"threshold_uncertainty_score":0.2750963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003997668228643594,"score_gpt":0.2196743965283663,"score_spread":0.2156767282997228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}