{"id":"W2037918682","doi":"10.1038/nm.3372","title":"Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin","year":2013,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":875,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McMaster University","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"AMPK; Metformin; Lipogenesis; Glucose homeostasis; Endocrinology; Internal medicine; AMP-activated protein kinase; Insulin resistance; Type 2 diabetes; Fatty liver; Fatty acid synthesis; Protein kinase A; Acetyl-CoA carboxylase; Fatty acid synthase; Energy homeostasis; Lipid metabolism; Chemistry; Biology; Phosphorylation; Insulin; Fatty acid; Pyruvate carboxylase; Diabetes mellitus; Biochemistry; Medicine; Enzyme; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001392243,0.0003944963,0.0002479266,0.0002678176,0.0002308897,0.0005249257,0.0002274112,0.000323992,0.002288418],"category_scores_gemma":[0.0001875884,0.0002358858,0.0002640885,0.000171268,0.0002607069,0.0003429448,0.0002448089,0.0006576345,0.000651947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002651916,"about_ca_system_score_gemma":0.000127779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002587528,"about_ca_topic_score_gemma":0.000506038,"domain_scores_codex":[0.9998908,0.0000115584,0.000007604543,0.00002991804,0.00003098512,0.00002903932],"domain_scores_gemma":[0.9998416,0.00001308109,0.00006369504,0.00001412087,0.00002362748,0.00004396247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001322018,0.00009809705,0.001974905,0.0002003571,0.00003804838,0.0002359624,0.00004464048,0.0002816746,0.9754155,0.001211912,0.001336486,0.01784055],"study_design_scores_gemma":[0.0003779593,0.001029474,0.1557312,0.0001340616,0.0002272306,0.002163978,0.0002220274,0.003627991,0.7922161,0.002746454,0.04144512,0.00007834441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944357,0.03648018,0.004298313,0.001371933,0.0007118186,0.00005791352,0.00076944,0.0003434975,0.01161001],"genre_scores_gemma":[0.9827544,0.0108009,0.001174392,0.0003163557,0.0001685135,0.00004797438,0.0004314048,0.00004750304,0.004258523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002288418,"threshold_uncertainty_score":0.007655561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003997668228643594,"score_gpt":0.2196743965283663,"score_spread":0.2156767282997228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}