{"id":"W2037965284","doi":"10.1089/hum.2008.009","title":"Protein <i>Trans</i> -Splicing as a Means for Viral Vector-Mediated <i>In Vivo</i> Gene Therapy","year":2008,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Muscular Dystrophy Association","keywords":"RNA splicing; Trans-splicing; Biology; Gene; Intron; Intein; Molecular biology; Viral vector; Genetic enhancement; Exon; Alternative splicing; Vector (molecular biology); RNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005769623,0.0005022963,0.0004590634,0.0001797854,0.0004089085,0.00004087197,0.0006555378,0.0003155559,0.000214839],"category_scores_gemma":[0.00001869826,0.0004810218,0.0003107681,0.0002657517,0.0002297988,0.00001332154,0.00004525886,0.0002502017,0.00002153371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006521607,"about_ca_system_score_gemma":0.000281954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000133251,"about_ca_topic_score_gemma":0.0002925589,"domain_scores_codex":[0.9969757,0.0002581291,0.0005174208,0.0008892062,0.00042806,0.0009314846],"domain_scores_gemma":[0.9985919,0.00003054318,0.0001329862,0.0008797843,0.0001666444,0.0001981538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00618481,0.0003599672,0.0002306267,0.00001336086,0.0001517357,0.00002865572,0.0004891087,0.00008404754,0.9901381,0.00002096285,0.000691162,0.001607502],"study_design_scores_gemma":[0.007279248,0.007277073,0.0002488268,0.00001545899,0.000003928387,0.00003379867,0.00002021544,0.00004564119,0.9564987,0.0002076581,0.02782553,0.0005439419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912615,0.005019425,0.000494522,0.0002406783,0.00007938915,0.002353678,0.00008766432,0.00007407368,0.0003890051],"genre_scores_gemma":[0.9892609,0.004690315,0.0004907374,0.001925149,0.0006816921,0.0009591844,0.000296761,0.0001960412,0.001499246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03363938,"threshold_uncertainty_score":0.9997641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03193612478457139,"score_gpt":0.298613536981668,"score_spread":0.2666774121970966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}