{"id":"W2037965284","doi":"10.1089/hum.2008.009","title":"Protein <i>Trans</i> -Splicing as a Means for Viral Vector-Mediated <i>In Vivo</i> Gene Therapy","year":2008,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Muscular Dystrophy Association","keywords":"RNA splicing; Trans-splicing; Biology; Gene; Intron; Intein; Molecular biology; Viral vector; Genetic enhancement; Exon; Alternative splicing; Vector (molecular biology); RNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006088103,0.0004833835,0.0002797297,0.0002697028,0.0002105586,0.0005229433,0.0003876657,0.0004758375,0.001259788],"category_scores_gemma":[0.0002516763,0.0002710959,0.0003624067,0.0001762445,0.0005696988,0.0003567796,0.0003893391,0.001169148,0.0008343037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000318082,"about_ca_system_score_gemma":0.0002833482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002031616,"about_ca_topic_score_gemma":0.0002520411,"domain_scores_codex":[0.9996,0.0001250542,0.00003402096,0.00006977985,0.0001335044,0.00003766696],"domain_scores_gemma":[0.9998374,0.00004368386,0.00004324011,0.00003515433,0.0000193995,0.00002102286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002359462,0.00002359138,0.00006864825,0.00003776606,0.000003622415,0.00003997947,0.00002651706,0.0001082204,0.9950147,0.001490422,0.00009802873,0.003064733],"study_design_scores_gemma":[0.000006656994,0.0001084773,0.0001623406,0.000003827686,0.000006912099,0.0003032284,0.000005922581,0.0006294462,0.9939144,0.0001172014,0.004737826,0.000003784608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5997235,0.005450222,0.3785614,0.0008126807,0.000476739,0.0004128225,0.0003945715,0.001196009,0.01297206],"genre_scores_gemma":[0.8389769,0.003547581,0.1416394,0.0002392478,0.0000643462,0.0002496999,0.000734607,0.0003508649,0.01419745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001259788,"threshold_uncertainty_score":0.004214346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03193612478457139,"score_gpt":0.298613536981668,"score_spread":0.2666774121970966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}