{"id":"W2037994659","doi":"10.1158/1078-0432.ovca13-b24","title":"Abstract B24: Using a unique genetically modified ovarian cancer cell line model to identify the targets for siRNA directed therapies","year":2013,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"","keywords":"Biology; Transcriptome; Ovarian cancer; Somatic cell; Missense mutation; Genetics; Gene; Cancer research; Cell culture; Synthetic lethality; Mutation; Cancer; DNA repair; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001350153,0.0002209952,0.0002322976,0.0002456876,0.0001936318,0.0002710318,0.0001672107,0.0002759918,0.001032622],"category_scores_gemma":[0.0001069579,0.00007942935,0.000277882,0.0002183586,0.0001603023,0.0001303079,0.0001590489,0.0005375422,0.0003840463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002428911,"about_ca_system_score_gemma":0.0001936388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001692697,"about_ca_topic_score_gemma":0.002454893,"domain_scores_codex":[0.9998647,0.00001215788,0.0000154162,0.00003086619,0.00005890605,0.00001798604],"domain_scores_gemma":[0.9998933,0.00001823043,0.00002365783,0.00002009308,0.00002335952,0.00002144588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002972426,0.0000137022,0.0001752169,0.00001268845,0.000003443338,0.00003267468,0.00000885033,0.0000628932,0.9991248,0.00003857218,0.00005977384,0.0004376665],"study_design_scores_gemma":[0.00001212236,0.0002869514,0.006388588,0.000003809396,0.00002338566,0.000233406,0.00004809298,0.001837242,0.9860458,0.00004639436,0.005066145,0.000008161249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841474,0.0006991195,0.009132915,0.0002066126,0.00009480875,0.0001088353,0.003302015,0.0001636896,0.002144564],"genre_scores_gemma":[0.9730749,0.0006106673,0.01374896,0.0001905295,0.0000140714,0.000207551,0.00550773,0.00007047743,0.00657507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001692697,"threshold_uncertainty_score":0.003454447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2137730228889519,"score_gpt":0.5268820149276521,"score_spread":0.3131089920387001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}