{"id":"W2038025308","doi":"10.1097/00002030-200102160-00017","title":"An argument for routine therapeutic drug monitoring of HIV-1 protease inhibitors during pregnancy","year":2001,"lang":"en","type":"article","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; Ottawa Hospital","funders":"","keywords":"Indinavir; Nelfinavir; Zidovudine; Medicine; Lamivudine; Pregnancy; Protease inhibitor (pharmacology); Pharmacokinetics; Internal medicine; Regimen; Gastroenterology; Pharmacology; Viral load; Immunology; Viral disease; Virus; Biology; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009608932,0.0001742493,0.0002647067,0.0001168519,0.00008337302,0.0000108037,0.0000687294,0.00004312083,0.00004234146],"category_scores_gemma":[0.00001504605,0.0001392999,0.00009800882,0.0001613354,0.00002523388,0.0001101791,0.00001969397,0.00007055826,0.00001546889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001061821,"about_ca_system_score_gemma":0.00005677912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008398109,"about_ca_topic_score_gemma":4.898596e-7,"domain_scores_codex":[0.9989288,0.00002330848,0.0003009367,0.0002470535,0.0002234852,0.0002764205],"domain_scores_gemma":[0.9994069,0.00002438072,0.00008612445,0.0002765702,0.00007307941,0.000132953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002198253,0.0006268413,0.9691125,0.000187666,0.0001711597,0.00004693679,0.001522517,0.000005038639,0.01161688,0.00005691678,0.00003464123,0.01639915],"study_design_scores_gemma":[0.009349717,0.0008995037,0.2567322,0.002088498,0.0004313466,0.00005052574,0.001238613,0.0001065045,0.7271351,0.0001878511,0.001389616,0.0003904426],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968704,0.0006122019,0.0001691764,0.0005775241,0.0001342531,0.00124623,0.00000510535,0.00007385132,0.0003112333],"genre_scores_gemma":[0.9836267,0.00007847606,0.004816249,0.000009825324,0.0002135782,0.0003124855,0.00002836966,0.00003214617,0.01088221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7155182,"threshold_uncertainty_score":0.5680484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01735807158925549,"score_gpt":0.2805689781276017,"score_spread":0.2632109065383462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}