{"id":"W2038045293","doi":"10.1097/01.fpc.0000220560.59972.33","title":"Gene–gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism","year":2007,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Center for Research Resources; Canada Research Chairs; National Institute on Drug Abuse; Health Canada; NIH Clinical Center; National Institutes of Health; Centre for Addiction and Mental Health","keywords":"CYP2A6; Nicotine; Cotinine; CYP2B6; Genotype; Pharmacogenetics; Metabolite; Pharmacology; Haplotype; Biology; Metabolism; Genetics; Medicine; Gene; Endocrinology; Internal medicine; Cytochrome P450; CYP3A4","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006910566,0.0003880619,0.0004362778,0.0004841187,0.0002584138,0.0003657802,0.0002145684,0.0004494879,0.003035583],"category_scores_gemma":[0.00133951,0.0001523832,0.0005982054,0.0006791791,0.0003362245,0.0001394075,0.0001775233,0.0003775807,0.0003779869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001854627,"about_ca_system_score_gemma":0.0002178516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002092135,"about_ca_topic_score_gemma":0.001711367,"domain_scores_codex":[0.9991587,0.0004568232,0.00003714295,0.0001524974,0.0001236343,0.00007110037],"domain_scores_gemma":[0.999019,0.0004547252,0.0002323056,0.00005426031,0.0001054631,0.0001341312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004033074,0.000316958,0.8867113,0.0001111802,0.001171629,0.001444751,0.0002055046,0.0008182176,0.08604465,0.0004615491,0.0003887786,0.01829243],"study_design_scores_gemma":[0.00007403193,0.0004262405,0.9913732,0.00001224472,0.0002849612,0.001224941,0.00004199956,0.00149665,0.003863718,0.0002344476,0.0009576639,0.000009906486],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948179,0.002328548,0.001667597,0.0002125549,0.00001983391,0.00002125447,0.0002493179,0.00002112388,0.000661819],"genre_scores_gemma":[0.9975665,0.0004590963,0.0012358,0.00003584405,0.00003324962,0.00001196442,0.0001589567,0.0000123886,0.0004861349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003035583,"threshold_uncertainty_score":0.01015502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01473730678911789,"score_gpt":0.3076562995420746,"score_spread":0.2929189927529567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}