{"id":"W2038049156","doi":"10.4161/chan.3.2.7932","title":"Ca <sub>V</sub> 2.1 P/Q-type calcium channel alternative splicing affects the functional impact of familial hemiplegic migraine mutations: Implications for calcium channelopathies","year":2009,"lang":"en","type":"article","venue":"Channels","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Canada Research Chairs; Heart and Stroke Foundation of Canada; National Ataxia Foundation","keywords":"Familial hemiplegic migraine; Calcium; Calcium channel; Mutation; Neuroscience; Alternative splicing; Migraine; Voltage-dependent calcium channel; Genetics; Chemistry; RNA splicing; Biophysics; Biology; Medicine; Internal medicine; Gene; Migraine with aura; Gene isoform","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000209519,0.0002343641,0.0002009632,0.0002361122,0.0001536942,0.0001805947,0.0001192602,0.0002795154,0.0008632705],"category_scores_gemma":[0.0004906759,0.00006222293,0.0001731102,0.0001305566,0.0002981321,0.0001678324,0.0001235857,0.0001672614,0.000114127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001396085,"about_ca_system_score_gemma":0.00009660998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003798378,"about_ca_topic_score_gemma":0.0004640936,"domain_scores_codex":[0.9998767,0.0000397273,0.0000181663,0.00002087083,0.00002401398,0.00002061552],"domain_scores_gemma":[0.9997783,0.0001014494,0.00004906083,0.00001806242,0.00002182974,0.00003121112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005844478,0.00003571172,0.00989212,0.00002827785,0.00001623041,0.001337087,0.00006017271,0.00009612271,0.9848145,0.0001185152,0.00004237876,0.00297452],"study_design_scores_gemma":[0.0001485957,0.002168049,0.343177,0.00002639035,0.0001711824,0.02306535,0.0003114671,0.001393248,0.6273633,0.0006690077,0.001485574,0.0000208507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991861,0.0003009581,0.0001976983,0.00002648577,0.000004111264,0.000003427841,0.00002625147,0.000002972587,0.0002518753],"genre_scores_gemma":[0.999527,0.0001241182,0.000211132,0.00002373355,0.000006515272,0.000003042374,0.00003102686,0.000003159549,0.00007026261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008632705,"threshold_uncertainty_score":0.002887964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07810246309629347,"score_gpt":0.3503198759654388,"score_spread":0.2722174128691454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}