{"id":"W2038049156","doi":"10.4161/chan.3.2.7932","title":"Ca <sub>V</sub> 2.1 P/Q-type calcium channel alternative splicing affects the functional impact of familial hemiplegic migraine mutations: Implications for calcium channelopathies","year":2009,"lang":"en","type":"article","venue":"Channels","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Canada Research Chairs; Heart and Stroke Foundation of Canada; National Ataxia Foundation","keywords":"Familial hemiplegic migraine; Calcium; Calcium channel; Mutation; Neuroscience; Alternative splicing; Migraine; Voltage-dependent calcium channel; Genetics; Chemistry; RNA splicing; Biophysics; Biology; Medicine; Internal medicine; Gene; Migraine with aura; Gene isoform","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003933245,0.0003771242,0.0006185676,0.0002715593,0.0004588964,0.0000218851,0.0001593231,0.0001381641,0.00001607075],"category_scores_gemma":[0.0005657881,0.00026184,0.0005262762,0.0006329333,0.0002025115,0.0001190474,0.00005057234,0.0002654174,0.00001582543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001671573,"about_ca_system_score_gemma":0.0002492492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001738068,"about_ca_topic_score_gemma":0.00004318164,"domain_scores_codex":[0.998193,0.00005208062,0.0004748176,0.0004399086,0.0002751893,0.0005649633],"domain_scores_gemma":[0.9979413,0.0004556105,0.0002704175,0.0004067658,0.0007514039,0.0001744965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001664827,0.001014551,0.002372973,0.000523933,0.001369918,0.00001603089,0.01740512,0.004586846,0.8237071,0.003744869,0.1411767,0.0024171],"study_design_scores_gemma":[0.008866871,0.009671256,0.3972788,0.0009903667,0.001494045,0.0004044807,0.006023405,0.01829702,0.5253673,0.02867558,0.001446309,0.001484583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722474,0.001861589,0.01369231,0.008937829,0.000312569,0.002073914,0.000288238,0.00009968424,0.0004864567],"genre_scores_gemma":[0.995919,0.0001956217,0.00008737457,0.0007186263,0.001856819,0.0002647958,0.0003634013,0.00003826874,0.0005560726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3949058,"threshold_uncertainty_score":0.9999834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07810246309629347,"score_gpt":0.3503198759654388,"score_spread":0.2722174128691454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}