{"id":"W2038050878","doi":"10.1016/j.tube.2014.11.004","title":"Association of polymorphisms in drug transporter genes (SLCO1B1 and SLC10A1) and anti-tuberculosis drug-induced hepatotoxicity in a Chinese cohort","year":2014,"lang":"en","type":"article","venue":"Tuberculosis","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Nanjing Medical University; Nanjing University; Natural Science Foundation of Beijing Municipality; National Natural Science Foundation of China; National Science Foundation","keywords":"SLCO1B1; Tuberculosis; Drug; Medicine; Gene; Pharmacology; Single-nucleotide polymorphism; Biology; Genetics; Genotype; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00109536,0.0003466578,0.001014847,0.0004057628,0.00005621642,0.00001585018,0.00009061225,0.0002253711,0.00005338138],"category_scores_gemma":[0.0000445834,0.0002914493,0.0001443901,0.0005499503,0.00006763579,0.0001704007,0.0000207289,0.000298549,0.000003155804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001238776,"about_ca_system_score_gemma":0.00003841719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002714892,"about_ca_topic_score_gemma":0.006990239,"domain_scores_codex":[0.9976776,0.0001231509,0.000738985,0.0005478784,0.000474523,0.000437826],"domain_scores_gemma":[0.9991453,0.0001167134,0.0001730638,0.0003062589,0.00007468732,0.0001840117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009744187,0.0002669983,0.922519,0.0002521082,0.0001130175,0.00002258362,0.001287706,0.000003691952,0.07317001,0.00004960466,0.00002260738,0.002195265],"study_design_scores_gemma":[0.002056994,0.00005325968,0.960761,0.0002955295,0.000256913,0.0000106117,0.00009732627,0.0004696238,0.03545232,0.0001673488,0.00008642349,0.0002927087],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957849,0.0006739009,0.00001828331,0.002088196,0.0001183016,0.0007065921,0.0000265557,0.0000467303,0.0005365343],"genre_scores_gemma":[0.9975346,0.001538772,0.0002196831,0.0002653392,0.00006591021,0.00005734127,0.00004347555,0.00004393996,0.0002308885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03824198,"threshold_uncertainty_score":0.9999537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004694274651606193,"score_gpt":0.2195524183289478,"score_spread":0.2148581436773416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}