{"id":"W2038070777","doi":"10.1210/en.2009-0826","title":"Role of Asparagine-Linked Glycosylation in Cell Surface Expression and Function of the Human Adrenocorticotropin Receptor (Melanocortin 2 Receptor) in 293/FRT Cells","year":2009,"lang":"en","type":"article","venue":"Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Glycosylation; Tunicamycin; N-linked glycosylation; Receptor; Biology; Melanocortin; Chinese hamster ovary cell; Mutant; G protein-coupled receptor; HEK 293 cells; Asparagine; Cell biology; Biochemistry; Molecular biology; Glycoprotein; Endoplasmic reticulum; Gene; Amino acid; Unfolded protein response","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001026105,0.000137874,0.0002280522,0.00007256034,0.00003673405,0.000004245689,0.0001403517,0.0001570393,0.00009842286],"category_scores_gemma":[0.00002450571,0.0001169813,0.00005445944,0.000121892,0.00005016863,0.00000697384,0.00007093273,0.0001520407,0.000001695725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001761178,"about_ca_system_score_gemma":0.00003118805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005731671,"about_ca_topic_score_gemma":0.0000397294,"domain_scores_codex":[0.9987586,0.0001564403,0.0004358311,0.0002922298,0.00009767818,0.0002592011],"domain_scores_gemma":[0.9994309,0.00001425251,0.0002375004,0.0002450865,0.00004119819,0.00003104818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001276474,0.00009343311,0.01069527,0.00001274853,0.000004249524,3.449463e-7,0.0001060581,0.0007511955,0.9863541,0.0001392517,0.0000636252,0.001652073],"study_design_scores_gemma":[0.0008599755,0.0004205538,0.03145795,0.00003164809,0.000005697782,0.000001398627,0.0001080373,0.00007354221,0.965753,0.0003412685,0.0008410723,0.0001059056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982105,0.0007530698,0.0002140813,0.00004892061,0.000149454,0.0002620335,0.000005106438,0.000005720769,0.0003510869],"genre_scores_gemma":[0.9987355,0.0002076628,0.0007752465,0.00002501968,0.00004662571,0.000007302809,0.00003020551,0.00001115784,0.0001612282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02076268,"threshold_uncertainty_score":0.4770357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006672473486117554,"score_gpt":0.2208918811363847,"score_spread":0.2142194076502671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}