{"id":"W2038070777","doi":"10.1210/en.2009-0826","title":"Role of Asparagine-Linked Glycosylation in Cell Surface Expression and Function of the Human Adrenocorticotropin Receptor (Melanocortin 2 Receptor) in 293/FRT Cells","year":2009,"lang":"en","type":"article","venue":"Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Glycosylation; Tunicamycin; N-linked glycosylation; Receptor; Biology; Melanocortin; Chinese hamster ovary cell; Mutant; G protein-coupled receptor; HEK 293 cells; Asparagine; Cell biology; Biochemistry; Molecular biology; Glycoprotein; Endoplasmic reticulum; Gene; Amino acid; Unfolded protein response","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002833834,0.0002402151,0.0002849469,0.0001311617,0.0001936071,0.0005473019,0.0002167601,0.0003141201,0.0006096672],"category_scores_gemma":[0.0001962225,0.000173389,0.0003637036,0.0001619042,0.0002152562,0.0002560003,0.0002077571,0.0004615121,0.0005832949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000321363,"about_ca_system_score_gemma":0.0002258199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001126189,"about_ca_topic_score_gemma":0.0009516812,"domain_scores_codex":[0.9997271,0.00006411187,0.00003589631,0.00005037942,0.00008503494,0.00003744727],"domain_scores_gemma":[0.9998721,0.00003081524,0.00003083453,0.00002307379,0.00001988986,0.00002323662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003886951,0.000007050132,0.0001047816,0.00001055148,0.00000194667,0.00003987595,0.00001368223,0.0000185194,0.999507,0.00003740095,0.000007598725,0.0002127946],"study_design_scores_gemma":[0.00001854643,0.0001299412,0.008403622,0.000006020985,0.00001765337,0.000828587,0.00005649025,0.001900921,0.9858835,0.00005053276,0.002694741,0.000009297707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911298,0.002422011,0.004450606,0.0001490503,0.00003850215,0.00003412875,0.0005592045,0.00006485498,0.001152007],"genre_scores_gemma":[0.9906616,0.001188061,0.004847908,0.000073594,0.00001322456,0.00003547321,0.001245426,0.00003793041,0.0018969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001126189,"threshold_uncertainty_score":0.002331614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006672473486117554,"score_gpt":0.2208918811363847,"score_spread":0.2142194076502671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}