{"id":"W2038080563","doi":"10.2174/1568011023353822","title":"Targeting Human Telomerase in Cancer Therapy","year":2002,"lang":"en","type":"review","venue":"Current Medicinal Chemistry - Anti-Cancer Agents","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Telomerase; Telomere; Telomerase reverse transcriptase; Ribonucleoprotein; Biology; Telomerase RNA component; Cancer; Cancer cell; Reverse transcriptase; RNA; Cancer research; Cell biology; Molecular biology; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004648141,0.0006262888,0.0007746957,0.001114333,0.0002715031,0.0005864274,0.0005954243,0.001147032,0.006128361],"category_scores_gemma":[0.0002301468,0.0001690058,0.0003430721,0.0009430795,0.0004265655,0.0008888224,0.0005199336,0.00150692,0.003080675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006854665,"about_ca_system_score_gemma":0.0005536568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005847932,"about_ca_topic_score_gemma":0.001583794,"domain_scores_codex":[0.9998506,0.00003466718,0.00001012323,0.00002296029,0.00006497959,0.00001658073],"domain_scores_gemma":[0.9999423,0.00001931075,0.00000961838,0.000003738968,0.00001495823,0.00001006585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001183192,0.0001671116,0.0001805387,0.004385498,0.0000467596,0.0005132888,0.00008102845,0.000640416,0.009095673,0.0123962,0.0411021,0.9312731],"study_design_scores_gemma":[0.00004405252,0.0001409675,0.0003848497,0.0007857519,0.00003721791,0.001614634,0.0000270958,0.0001373741,0.001658256,0.003091124,0.992069,0.000009737618],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005093003,0.9918714,0.0007094112,0.0007321628,0.0005550672,0.00001853281,0.00001908962,0.00002390195,0.005561212],"genre_scores_gemma":[0.004699652,0.9859066,0.001081284,0.001025999,0.0004076691,0.00002819168,0.0000519782,0.000004919993,0.006793619],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006128361,"threshold_uncertainty_score":0.02050143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1431869122676144,"score_gpt":0.4579561692425274,"score_spread":0.314769256974913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}