{"id":"W2038083698","doi":"10.1158/0008-5472.can-04-4424","title":"Src Homology 2–Containing Inositol 5′-Phosphatase 1 Negatively Regulates IFN-γ Production by Natural Killer Cells Stimulated with Antibody-Coated Tumor Cells and Interleukin-12","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; BC Cancer Agency","keywords":"Interleukin 12; Janus kinase 3; Interleukin 21; Cell biology; Cytokine; Biology; Molecular biology; Immune system; Chemistry; T cell; Immunology; Cytotoxic T cell; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001229932,0.0003177429,0.0003258646,0.0001520494,0.0001180755,0.000341665,0.0001691196,0.0001576681,0.0008040679],"category_scores_gemma":[0.0001225129,0.0001443863,0.0002423627,0.0001213701,0.0002147319,0.0001766916,0.0001994359,0.0004862079,0.0003546212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002469633,"about_ca_system_score_gemma":0.0002697246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004466985,"about_ca_topic_score_gemma":0.0005946066,"domain_scores_codex":[0.9998616,0.00001807936,0.00001517139,0.00002325398,0.00003379339,0.00004800508],"domain_scores_gemma":[0.9999368,0.00001042384,0.00002030917,0.000007424752,0.000008769146,0.00001620914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000179797,0.00002297667,0.0003454044,0.00002901644,0.00000394851,0.000060132,0.00001631837,0.00005192871,0.9985315,0.0000471563,0.00002857764,0.0006833325],"study_design_scores_gemma":[0.00004341385,0.0001839113,0.01399664,0.000006970828,0.00002220458,0.000278351,0.00006295712,0.001615881,0.9820911,0.00005991282,0.001632617,0.000005932506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964619,0.001448258,0.0007960249,0.00007145582,0.00002911124,0.00001304777,0.0001335363,0.0000285618,0.001018173],"genre_scores_gemma":[0.9969434,0.0007885158,0.0004120637,0.00003912218,0.00001190763,0.00002451788,0.0003289168,0.000008311041,0.001443198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008040679,"threshold_uncertainty_score":0.002689898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01888988464740017,"score_gpt":0.3144597215425297,"score_spread":0.2955698368951296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}