{"id":"W2038084537","doi":"10.1211/0022357021567","title":"Delivery of an anticancer drug and a chemosensitizer to murine breast sarcoma by intratumoral injection of sulfopropyl dextran microspheres","year":2003,"lang":"en","type":"article","venue":"Journal of Pharmacy and Pharmacology","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"University of Toronto","keywords":"Doxorubicin; Pharmacology; Chemosensitizer; Verapamil; In vivo; Toxicity; Anthracycline; Chemistry; Medicine; Sarcoma; P-glycoprotein; Ex vivo; Chemotherapy; In vitro; Cancer; Pathology; Internal medicine; Breast cancer; Cytotoxicity; Multiple drug resistance; Biology; Calcium; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002813548,0.0004344066,0.0003515534,0.0003229848,0.00009090055,0.0002882248,0.0002098129,0.0003713483,0.0005836091],"category_scores_gemma":[0.0001228346,0.0002076292,0.0002540391,0.0001679781,0.0001916536,0.0002860026,0.0001582243,0.0004255786,0.0002412443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000313071,"about_ca_system_score_gemma":0.0002338088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005570732,"about_ca_topic_score_gemma":0.0008231469,"domain_scores_codex":[0.9997904,0.00003354036,0.00001735288,0.00005506599,0.00005531411,0.00004832913],"domain_scores_gemma":[0.9998739,0.00002256612,0.00004421546,0.00001671997,0.0000153456,0.00002724235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007288734,0.0000342539,0.00003972704,0.00001802522,0.000003005816,0.00001919673,0.000009391639,0.00007811032,0.9986787,0.00005535973,0.00001163551,0.0009797752],"study_design_scores_gemma":[0.00002194504,0.000767527,0.0005653795,0.000002083126,0.00001467916,0.00009095619,0.000005122581,0.0008924849,0.9965985,0.00001561144,0.001021963,0.00000367228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905648,0.001520824,0.006499426,0.00007480312,0.00003896734,0.00009942159,0.0002071478,0.0001219877,0.0008724978],"genre_scores_gemma":[0.9852068,0.00126816,0.01026837,0.00002793778,0.00002519735,0.0000844887,0.0002634559,0.00003977794,0.002815712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005836091,"threshold_uncertainty_score":0.002271533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008522263674638701,"score_gpt":0.2750062972819223,"score_spread":0.2664840336072836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}