{"id":"W2038120217","doi":"10.1038/npp.2011.107","title":"Increasing CREB Function in the CA1 Region of Dorsal Hippocampus Rescues the Spatial Memory Deficits in a Mouse Model of Alzheimer's Disease","year":2011,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Alzheimer's Society","keywords":"Neuroscience; Hippocampus; CREB; Dorsum; Disease; Psychology; Alzheimer's disease; Function (biology); Biology; Medicine; Internal medicine; Anatomy; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002640469,0.0009672905,0.000902077,0.0008930133,0.0003931245,0.0005418182,0.0009219483,0.0008558701,0.002300541],"category_scores_gemma":[0.0002041774,0.0004896086,0.0005818465,0.0002788935,0.001077692,0.0005534455,0.0003815716,0.00256858,0.0006304994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005450922,"about_ca_system_score_gemma":0.0006003163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002097175,"about_ca_topic_score_gemma":0.003908421,"domain_scores_codex":[0.9997491,0.00001841567,0.00002031648,0.0000542921,0.00005840511,0.00009946297],"domain_scores_gemma":[0.999712,0.00002310903,0.00007818473,0.00003928654,0.00003140325,0.0001158704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003937209,0.0001165444,0.00006962918,0.00007940352,0.00001424715,0.00008248302,0.00002207058,0.00006707248,0.9970117,0.0002305055,0.0001340299,0.001778608],"study_design_scores_gemma":[0.0001442375,0.0006833861,0.002314617,0.00002649878,0.00007696584,0.0002974385,0.00007571113,0.0007292588,0.9932188,0.0003552344,0.002059605,0.00001826471],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890844,0.003223287,0.003886419,0.000740786,0.0002379765,0.00003737693,0.0007463525,0.0004718985,0.001571593],"genre_scores_gemma":[0.9847566,0.002703645,0.003480101,0.000213708,0.00005425422,0.00008450811,0.0006026117,0.0001287109,0.007975886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002300541,"threshold_uncertainty_score":0.007696033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06125300591276962,"score_gpt":0.3214193967370624,"score_spread":0.2601663908242928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}