{"id":"W2038146919","doi":"10.1371/journal.pone.0069604","title":"Validation of Next Generation Sequencing Technologies in Comparison to Current Diagnostic Gold Standards for BRAF, EGFR and KRAS Mutational Analysis","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast","keywords":"KRAS; Sanger sequencing; DNA sequencing; Gold standard (test); Computational biology; Ion semiconductor sequencing; Bioinformatics; Medicine; Gene; Colorectal cancer; Biology; Oncology; Cancer; Genetics; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001133204,0.00007338424,0.0001652976,0.0001241991,0.00002250731,0.00003378028,0.00005703028,0.00005845737,0.000005716337],"category_scores_gemma":[0.0008952126,0.00007862853,0.00003051324,0.0001598721,0.00002570116,0.000006888309,0.00004597275,0.00003359848,7.678473e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006504629,"about_ca_system_score_gemma":0.0000794994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008368165,"about_ca_topic_score_gemma":0.0002498288,"domain_scores_codex":[0.9993494,0.00001277329,0.0002181941,0.0001916263,0.0001264049,0.0001015893],"domain_scores_gemma":[0.9994462,0.00008554947,0.00007757097,0.0001218221,0.0002423248,0.00002651725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001842673,0.0002140264,0.04518095,0.00007772762,0.0001981835,1.440534e-7,0.0001334648,0.00768258,0.9380902,0.0001305891,0.0004641212,0.007809567],"study_design_scores_gemma":[0.0003871216,0.0002655311,0.00643495,0.00004662431,0.0002448403,1.97746e-7,0.0001935271,0.01828824,0.973543,0.0003018064,0.0001503064,0.0001438037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871495,0.0014173,0.01060375,0.000209542,0.00002244451,0.0004319527,0.0001476334,0.00000668646,0.0000112144],"genre_scores_gemma":[0.9940018,0.000412404,0.004919866,0.00002480324,0.00005396843,0.0001779668,0.0003959183,0.000006953428,0.000006313285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.038746,"threshold_uncertainty_score":0.3206378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07484327734445759,"score_gpt":0.2932819876830726,"score_spread":0.218438710338615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}