{"id":"W2038151468","doi":"10.1093/bja/aeh181","title":"Physicochemical properties of neuromuscular blocking agents and their impact on the pharmacokinetic–pharmacodynamic relationship","year":2004,"lang":"en","type":"article","venue":"British Journal of Anaesthesia","topic":"Anesthesia and Sedative Agents","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Chemistry; Pharmacodynamics; Pharmacokinetics; Potency; Pharmacology; Solubility; Free fraction; Chromatography; In vitro; Biochemistry; Medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009216198,0.0002350022,0.0003896484,0.0002500027,0.0001964943,0.0007545944,0.0002028865,0.0004741112,0.002158412],"category_scores_gemma":[0.005159603,0.0003090797,0.0005388485,0.0002415605,0.0003548407,0.0007029444,0.0002658569,0.0008562473,0.0006305069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002707245,"about_ca_system_score_gemma":0.0002647384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004828969,"about_ca_topic_score_gemma":0.0002364302,"domain_scores_codex":[0.9993887,0.0003190102,0.00004675484,0.00005109432,0.0001492783,0.00004515711],"domain_scores_gemma":[0.9968772,0.002138045,0.0005354312,0.0001123509,0.0002243012,0.0001126917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01103301,0.0004929526,0.0254824,0.0007423031,0.0007703913,0.00152686,0.0002445845,0.009068197,0.8598958,0.002979559,0.001295108,0.08646891],"study_design_scores_gemma":[0.0007714797,0.01151867,0.2374895,0.00009055991,0.001109175,0.01127119,0.0003840732,0.04480103,0.6681414,0.005074801,0.01913994,0.0002082204],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731417,0.01231847,0.007026265,0.0006742937,0.0001615591,0.00006704282,0.0003211252,0.00005504105,0.006234429],"genre_scores_gemma":[0.9934797,0.003605922,0.001600248,0.0001488007,0.0001423998,0.00002432238,0.0001479288,0.00003946945,0.000811296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002158412,"threshold_uncertainty_score":0.007220566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03307676578878565,"score_gpt":0.2775915840676248,"score_spread":0.2445148182788391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}