{"id":"W2038168590","doi":"10.1128/mcb.21.2.400-413.2001","title":"Irradiation Promotes V(D)J Joining and RAG-Dependent Neoplastic Transformation in SCID T-Cell Precursors","year":2001,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; Medical Research Council; Medical Research Council Canada; Hospital for Sick Children","keywords":"Biology; V(D)J recombination; Cancer research; Carcinogenesis; Molecular biology; DNA damage; Non-homologous end joining; Recombinase; DNA repair; Severe combined immunodeficiency; DNA; Cell biology; Gene; Genetics; Recombination","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001571989,0.0003172915,0.0001690379,0.0003215512,0.0001344046,0.0002519647,0.000179291,0.000220357,0.001362848],"category_scores_gemma":[0.0001568799,0.0001555238,0.0002105046,0.000125082,0.0001929113,0.0001430454,0.0002085889,0.0004074057,0.0005090051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001947751,"about_ca_system_score_gemma":0.0001430165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002865193,"about_ca_topic_score_gemma":0.0004783971,"domain_scores_codex":[0.9998187,0.00003873297,0.00002027049,0.00003312899,0.000052327,0.00003682967],"domain_scores_gemma":[0.9998197,0.00003669644,0.00005260705,0.00003066922,0.00001198872,0.00004833852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005619421,0.00001885229,0.0001086411,0.00001411079,0.000002287236,0.00002806118,0.000008677526,0.00003813755,0.9992161,0.00005368372,0.00001073543,0.0004444978],"study_design_scores_gemma":[0.00001184482,0.0003998053,0.004122969,0.000004424036,0.000007735468,0.0002692103,0.00001649649,0.0003043709,0.9935766,0.00002542979,0.001259179,0.000002046507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935108,0.001310878,0.002181086,0.00004074312,0.00001260553,0.00003589503,0.0002364265,0.0001528152,0.002518796],"genre_scores_gemma":[0.9957213,0.0006069439,0.001108716,0.00002687933,0.000007504419,0.00003266281,0.0003702775,0.0000230314,0.002102632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001362848,"threshold_uncertainty_score":0.004559219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005037681952841156,"score_gpt":0.2055544371990202,"score_spread":0.200516755246179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}