{"id":"W2038206418","doi":"10.1002/biof.170","title":"Human neural tube defects: Genetic causes and prevention","year":2011,"lang":"en","type":"review","venue":"BioFactors","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fondazione Telethon","keywords":"Convergent extension; Neurulation; Dishevelled; Neural tube; Biology; Gastrulation; Genetics; Frizzled; Missense mutation; Wnt signaling pathway; Neural plate; Gene; Candidate gene; Cell biology; Mutation; Embryogenesis; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0000852287,0.0003459888,0.0005113209,0.0001243522,0.00009263103,0.00003510155,0.0002368503,0.0003841142,0.0001117403],"category_scores_gemma":[0.00008468075,0.0003014177,0.000263508,0.0001054214,0.0001212885,0.000002740848,0.000242066,0.0001810533,0.00002391356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002223328,"about_ca_system_score_gemma":0.00009937669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007519357,"about_ca_topic_score_gemma":0.0001118155,"domain_scores_codex":[0.9985507,0.0002052346,0.0002671875,0.0005735449,0.0001021941,0.0003011292],"domain_scores_gemma":[0.9992845,0.00001287247,0.0001277565,0.0004116095,0.00005081897,0.0001124391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005921982,0.00006331021,0.001049339,0.00366756,0.0002501933,0.000007746789,0.00002731692,6.628596e-8,0.001083021,0.00002239438,0.0004809944,0.9933422],"study_design_scores_gemma":[0.000152625,0.0003991882,0.001622117,0.000449091,0.0002046773,0.00002676478,0.00001250286,1.978455e-7,0.000225234,0.00003299952,0.9964728,0.0004018034],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03750307,0.9614352,0.00001063235,0.000001311243,0.00009472702,0.0006358601,0.00003497346,0.0000162508,0.0002679709],"genre_scores_gemma":[0.00661973,0.99181,0.0000263979,0.000006092536,0.0001407289,0.0000876842,0.0002347937,0.0000689528,0.001005612],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9959918,"threshold_uncertainty_score":0.9999438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08491983930010237,"score_gpt":0.3796433307485069,"score_spread":0.2947234914484045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}